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Tbio
NSMCE2
E3 SUMO-protein ligase NSE2

Protein Summary
Description
E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287437
  • ENSP00000287437
  • ENSG00000156831
  • ENST00000522563
  • ENSP00000430668

Symbol
  • C8orf36
  • MMS21
  • NSE2
  • MMS21
  • ZMIZ7
  • C8orf36
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.91
biological process
0.87
histone modification site profile
0.87
kinase perturbation
0.66
tissue sample
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.43   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.43   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (106)
ZNF597
Tbio
Family:  TF
Novelty:  0.04420398
p_int:  0.999999834
p_ni:  5.4e-8
p_wrong:  1.12e-7
Score:  0.847
Data Source:  BioPlex,STRINGDB
NSMCE1
Tdark
Novelty:  0.75370409
p_int:  0.999999757
p_ni:  2.3e-8
p_wrong:  2.2e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
EID3
Tdark
Novelty:  0.37412011
p_int:  0.997270196
p_ni:  0.00002852
p_wrong:  0.002701285
Score:  0.995
Data Source:  BioPlex,STRINGDB
SMC6
Tbio
Novelty:  0.02450073
Score:  0.999
Data Source:  STRINGDB
NSMCE3
Tbio
Novelty:  0.04335295
Score:  0.999
Data Source:  STRINGDB
SMC5
Tbio
Novelty:  0.008623
Score:  0.999
Data Source:  STRINGDB
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.996
Data Source:  STRINGDB
SMC3
Tbio
Novelty:  0.00474377
Score:  0.986
Data Source:  STRINGDB
NSMCE4A
Tdark
Novelty:  0.45550673
Score:  0.981
Data Source:  STRINGDB
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.977
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Reactome
SUMOylation
Reactome
SUMOylation of DNA damage response and repair proteins
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of DNA damage response and repair proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
5
9
10
99.7
low density lipoprotein cholesterol measurement
3
6
7
98.5
apolipoprotein B measurement
1
6
6
95.8
total cholesterol measurement
2
6
6
93.4
C-reactive protein measurement
3
3
3
90.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
10
99.7
low density lipoprotein cholesterol measurement
7
98.5
apolipoprotein B measurement
6
95.8
total cholesterol measurement
6
93.4
C-reactive protein measurement
3
90.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
VGNC:10218
464387
Macaque
NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
707064
Mouse
MGI:1915751
68501
Rat
RGD:1305156
299957
Horse
NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
VGNC:20906
100067659
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
Macaque
NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
Mouse
Rat
Horse
NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
Publication Statistics
PubMed Score 46.43
PubMed score by year
PubTator Score 15.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title