You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
C12orf66
KICSTOR complex protein C12orf66

Protein Summary
Description
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398055
  • ENSP00000381132
  • ENSG00000174206
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.39   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 9   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.39   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 9   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
26.6
mathematical ability
1
1
1
21.5
cognitive function measurement
1
1
1
14.2
heel bone mineral density
1
1
1
9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
26.6
mathematical ability
1
21.5
cognitive function measurement
1
14.2
heel bone mineral density
1
9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromosome 12 C12orf66 homolog
VGNC:5308
745077
Macaque
chromosome 11 open reading frame, human C12orf66
717230
Mouse
MGI:2670984
270802
Rat
RGD:1565498
500843
Dog
chromosome 10 C12orf66 homolog
VGNC:52479
474426
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromosome 12 C12orf66 homolog
Macaque
chromosome 11 open reading frame, human C12orf66
Mouse
Rat
Dog
chromosome 10 C12orf66 homolog
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96MD2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (40)
1 – 10 of 40
ITFG2
Tbio
Novelty:  0.41720651
p_int:  0.999999963
p_ni:  3.7e-8
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
BMT2
Tbio
Family:  Enzyme
Novelty:  0.05916379
p_int:  0.999999918
p_ni:  1.9e-8
p_wrong:  6.3e-8
Score:  0.873
Data Source:  BioPlex,Reactome,STRINGDB
KPTN
Tbio
Novelty:  0.06841936
p_int:  0.999999342
p_ni:  1.43e-7
p_wrong:  5.15e-7
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
DEPDC5
Tbio
Novelty:  0.0177511
p_int:  0.996837934
p_ni:  0.000282394
p_wrong:  0.002879672
Score:  0.95
Data Source:  BioPlex,Reactome,STRINGDB
SZT2
Tbio
Novelty:  0.06995258
Score:  0.984
Data Source:  Reactome,STRINGDB
FAM185A
Tdark
Novelty:  2.58347979
Score:  0.669
Data Source:  STRINGDB
WDR59
Tdark
Novelty:  0.22243351
Score:  0.622
Data Source:  STRINGDB
WDR24
Tdark
Novelty:  0.48411996
Score:  0.619
Data Source:  STRINGDB
SEH1L
Tbio
Novelty:  0.03666501
Score:  0.606
Data Source:  STRINGDB
MIOS
Tdark
Novelty:  0.04252507
Score:  0.605
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.39

PubMed score by year
PubTator Score  0.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer