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Tbio
AK8
Adenylate kinase 8

Protein Summary
Description
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298545
  • ENSP00000298545
  • ENSG00000165695

Symbol
  • C9orf98
  • AK 8
  • DDX31
  • C9orf98
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
histone modification site profile
0.87
tissue sample
0.64
cell line
0.55
phenotype
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.78   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.78   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
83.5
self reported educational attainment
1
1
1
73.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
83.5
self reported educational attainment
1
73.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenylate kinase 8
VGNC:4606
464817
Macaque
adenylate kinase 8
714698
Mouse
MGI:1916120
68870
Rat
RGD:1303144
311833
Dog
adenylate kinase 8
VGNC:37749
480689
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenylate kinase 8
Macaque
adenylate kinase 8
Mouse
Rat
Dog
adenylate kinase 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96MA6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Protein-Protein Interactions (131)
1 – 10 of 131
ADK
Tchem
Family: Kinase
Novelty: 0.00196435
Score: 0.964
Data Source: STRINGDB
APRT
Tbio
Family: Enzyme
Novelty: 0.00483077
Score: 0.961
Data Source: STRINGDB
ADSL
Tbio
Family: Enzyme
Novelty: 0.0028496
Score: 0.942
Data Source: STRINGDB
ENTPD2
Tchem
Family: Enzyme
Novelty: 0.00132093
Score: 0.937
Data Source: STRINGDB
ATP5F1A
Tbio
Family: Enzyme
Novelty: 0.01052213
Score: 0.924
Data Source: STRINGDB
ATP5F1C
Tbio
Family: Enzyme
Novelty: 0.07666564
Score: 0.924
Data Source: STRINGDB
ATP5F1B
Tbio
Family: Enzyme
Novelty: 0.01053177
Score: 0.922
Data Source: STRINGDB
RRM1
Tclin
Family: Enzyme
Novelty: 0.00083196
Score: 0.915
Data Source: STRINGDB
MT-ATP6
Tbio
Family: Enzyme
Novelty: 0.00104191
Score: 0.915
Data Source: STRINGDB
PNPT1
Tbio
Family: Enzyme
Novelty: 0.00339969
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.78

PubMed score by year
PubTator Score  4.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer