Tbio PACRG Parkin coregulated gene protein

Protein Summary

Description

Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease. This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96M98
• E1P5B5
• Q6IMB8
• Q8IZM1
• Q8NHP5
• Q9H1V9

Gene Name

• PACRG

Ensembl ID

• ENST00000337019
• ENSP00000337946
• ENSG00000112530
• ENST00000366888
• ENSP00000355854
• ENST00000366889
• ENSP00000355855

Symbol

• GLUP
• GLUP
• PACRG2.1
• PARK2CRG
• HAK005771

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.99
phenotype	0.71
gene perturbation	0.7
histone modification site profile	0.67
transcription factor	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.57   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.57   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0