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Tbio
CFAP53
Cilia- and flagella-associated protein 53

Protein Summary
Description
May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. This gene belongs to the CFAP53 family. It was found to be differentially expressed by the ciliated cells of frog epidermis and in skin fibroblasts from human. Mutations in this gene are associated with visceral heterotaxy-6, which implicates this gene in determination of left-right asymmetric patterning. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398545
  • ENSP00000381553
  • ENSG00000172361

Symbol
  • CCDC11
  • HTX6
  • CCDC11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
virus perturbation
0.76
tissue sample
0.6
histone modification site profile
0.58
cell line
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
CFAP57
Tdark
Novelty:  0.33594432
Score:  0.729
Data Source:  STRINGDB
MKLN1
Tbio
Novelty:  0.05014385
Score:  0.725
Data Source:  STRINGDB
RTN1
Tbio
Novelty:  0.01828064
Score:  0.705
Data Source:  STRINGDB
RPS3
Tbio
Novelty:  0.003106
Score:  0.668
Data Source:  STRINGDB
CFAP52
Tbio
Novelty:  0.23267809
Score:  0.668
Data Source:  STRINGDB
WNT2B
Tbio
Novelty:  0.00783711
Score:  0.655
Data Source:  STRINGDB
RALA
Tbio
Family:  Enzyme
Novelty:  0.00257914
Score:  0.624
Data Source:  STRINGDB
SYT13
Tbio
Novelty:  0.03332595
Score:  0.55
Data Source:  STRINGDB
CCDC151
Tbio
Novelty:  0.15952702
Score:  0.547
Data Source:  STRINGDB
SDK2
Tdark
Novelty:  0.08867136
Score:  0.541
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
2
2
93
high density lipoprotein cholesterol measurement
3
2
3
91.6
total cholesterol measurement
1
1
1
70.5
phospholipid measurement
1
1
1
21.5
high density lipoprotein particle size measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
93
high density lipoprotein cholesterol measurement
3
91.6
total cholesterol measurement
1
70.5
phospholipid measurement
1
21.5
high density lipoprotein particle size measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cilia and flagella associated protein 53
VGNC:5151
468534
Macaque
cilia and flagella associated protein 53
700084
Mouse
MGI:1921703
74453
Rat
RGD:1306734
364899
Dog
cilia and flagella associated protein 53
VGNC:39165
490567
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cilia and flagella associated protein 53
Macaque
cilia and flagella associated protein 53
Mouse
Rat
Dog
cilia and flagella associated protein 53
Publication Statistics
PubMed Score 13.00
PubMed score by year
PubTator Score 6.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title