Tbio CCDC114 Coiled-coil domain-containing protein 114

Protein Summary

Description

Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. This gene encodes a coiled-coil domain-containing protein that is a component of the outer dynein arm docking complex in cilia cells. Mutations in this gene may cause primary ciliary dyskinesia 20. [provided by RefSeq, May 2013]

Uniprot Accession IDs

• Q96M63
• Q6ZRL4
• Q96M06
• Q9UFG8

Gene Name

• CCDC114

Ensembl ID

• ENST00000315396
• ENSP00000318429
• ENSG00000105479

Symbol

• CILD20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.69
cell type or tissue	0.63
tissue sample	0.6
transcription factor binding site profile	0.59
tissue	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.05   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 65   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.05   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0