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Tbio
TBATA
Protein TBATA

Protein Summary
Description
May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function. This gene encodes a protein that regulates thymic epithelial cell proliferation and thymus size. It has been identified as a ligand for the class I human leukocyte antigen (HLA-I) in thymus. Studies of the orthologous mouse protein suggest that it may also play a role in spermatid differentiation, as well as in neuronal morphogenesis and synaptic plasticity. Polymorphisms in this gene are associated with susceptibility for multiple sclerosis (MS). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299290
  • ENSP00000299290
  • ENSG00000166220

Symbol
  • C10orf27
  • SPATIAL
  • SPATIAL
  • C10orf27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.65
cell line
0.49
virus perturbation
0.45
tissue
0.44
transcription factor
0.42


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.63   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.63   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
3
5
92.2
reticulocyte count
2
2
2
71.3
reticulocyte measurement
3
2
3
64.9
body fat distribution
2
1
4
61
red blood cell distribution width
2
1
2
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
5
92.2
reticulocyte count
2
71.3
reticulocyte measurement
3
64.9
body fat distribution
4
61
red blood cell distribution width
2
57.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thymus, brain and testes associated
VGNC:7265
749032
Macaque
thymus, brain and testes associated
710055
Mouse
MGI:1923820
65971
Rat
RGD:1561665
499429
Dog
thymus, brain and testes associated
VGNC:47128
609672
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thymus, brain and testes associated
Macaque
thymus, brain and testes associated
Mouse
Rat
Dog
thymus, brain and testes associated
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96M53-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (22)
1 – 10 of 22
SPECC1L
Tbio
Novelty:  0.06116909
Score:  0.669
Data Source:  STRINGDB
PALD1
Tbio
Novelty:  0.0248863
Score:  0.661
Data Source:  STRINGDB
NCLN
Tbio
Novelty:  0.10851333
Score:  0.649
Data Source:  STRINGDB
INCA1
Tbio
Novelty:  0.07681987
Score:  0.644
Data Source:  STRINGDB
DENND3
Tbio
Novelty:  0.16702884
Score:  0.561
Data Source:  STRINGDB
CKAP2L
Tbio
Novelty:  0.12663454
Score:  0.533
Data Source:  STRINGDB
ADAMTS14
Tbio
Family:  Enzyme
Novelty:  0.07885034
Score:  0.531
Data Source:  STRINGDB
VEZF1
Tbio
Family:  TF
Novelty:  0.00309596
Score:  0.525
Data Source:  STRINGDB
AKAP14
Tbio
Family:  Enzyme
Novelty:  0.50699923
Score:  0.515
Data Source:  STRINGDB
MPPED1
Tdark
Family:  Enzyme
Novelty:  0.58103321
Score:  0.515
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.63

PubMed score by year
PubTator Score  17.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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