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Tbio
PRIMPOL
DNA-directed primase/polymerase protein

Protein Summary
Description
DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. Required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. Has non-overlapping function with POLH. This gene encodes a DNA primase-polymerase that belongs to a superfamily of archaeao-eukaryotic primases. Members of this family have primase activity, catalyzing the synthesis of short RNA primers that serve as starting points for DNA synthesis, as well as DNA polymerase activity. The encoded protein facilitates DNA damage tolerance by mediating uninterrupted fork progression after UV irradiation and reinitiating DNA synthesis. An a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314970
  • ENSP00000313816
  • ENSG00000164306
  • ENST00000503752
  • ENSP00000420860
  • ENST00000512834
  • ENSP00000425316

Symbol
  • CCDC111
  • MYP22
  • CCDC111
  • Primpol1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
transcription factor binding site profile
0.73
tissue sample
0.68
molecular function
0.67
histone modification site profile
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.38   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.38   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
2
1.1
87.7
1
1
0
1.4
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
87.7
0
1.4
17.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
primase and DNA directed polymerase
VGNC:2964
471370
Macaque
primase and DNA directed polymerase
694608
Mouse
MGI:3603756
408022
Rat
RGD:1562119
361147
Dog
primase and DNA directed polymerase
VGNC:44968
475632
Species
Name
OMA
EggNOG
Inparanoid
Chimp
primase and DNA directed polymerase
Macaque
primase and DNA directed polymerase
Mouse
Rat
Dog
primase and DNA directed polymerase
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96LW4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (56)
1 – 10 of 56
TWNK
Tbio
Novelty:  0.00393371
p_int:  0.9999972
p_ni:  0.0000028
Score:  0.672
Data Source:  BioPlex,STRINGDB
NEURL4
Tdark
Novelty:  0.20430708
p_int:  0.999471442
p_ni:  0.000528557
Score:  0.159
Data Source:  BioPlex,STRINGDB
HERC2
Tbio
Family:  Enzyme
Novelty:  0.06552683
p_int:  0.999135313
p_ni:  0.000864687
Score:  0.191
Data Source:  BioPlex,STRINGDB
ECI2
Tbio
Family:  Enzyme
Novelty:  0.02317646
p_int:  0.914430412
p_ni:  0.085569588
Score:  0.239
Data Source:  BioPlex,STRINGDB
ABHD18
Tdark
Novelty:  10.43528841
p_int:  0.873090941
p_ni:  0.126025302
p_wrong:  0.000883757
Score:  0.234
Data Source:  BioPlex,STRINGDB
RSPRY1
Tdark
Novelty:  0.26883105
p_int:  0.835490371
p_ni:  0.164509598
p_wrong:  3.1e-8
Data Source:  BioPlex
RPA1
Tchem
Novelty:  0.00212665
Score:  0.999
Data Source:  STRINGDB
CLSPN
Tbio
Novelty:  0.01330727
Score:  0.994
Data Source:  STRINGDB
SMARCAL1
Tbio
Novelty:  0.01436868
Score:  0.994
Data Source:  STRINGDB
RPA2
Tbio
Novelty:  0.00879115
Score:  0.994
Data Source:  STRINGDB
Publication Statistics
PubMed Score  102.38

PubMed score by year
PubTator Score  31.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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