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Tbio
IMMP1L
Mitochondrial inner membrane protease subunit 1

Protein Summary
Description
Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO. The mitochondrial inner membrane peptidase (IMP) complex generates mature, active proteins in the mitochondrial intermembrane space by proteolytically removing the mitochondrial targeting presequence of nuclear-encoded proteins. IMP1 and IMP2 (IMMP2L; MIM 605977) are the catalytic subunits of the IMP complex (Burri et al., 2005 [PubMed 15814844]).[supplied by OMIM, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278200
  • ENSP00000278200
  • ENSG00000148950
  • ENST00000532287
  • ENSP00000435576

Symbol
  • IMP1
  • IMMP1
  • IMP1-LIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor perturbation
0.74
protein domain
0.73
virus perturbation
0.72
disease perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.86   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.86   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
1
2
73.2
cortical surface area measurement
1
1
0
7.7
59.5
optic disc area measurement
2
2
3
59.4
erythrocyte count
1
1
1
56
cup-to-disc ratio measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
73.2
cortical surface area measurement
0
7.7
59.5
optic disc area measurement
3
59.4
erythrocyte count
1
56
cup-to-disc ratio measurement
1
40.7
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inner mitochondrial membrane peptidase subunit 1
VGNC:1067
466478
Macaque
inner mitochondrial membrane peptidase subunit 1
696105
Mouse
MGI:1913791
66541
Rat
RGD:1587441
691145
Dog
inner mitochondrial membrane peptidase subunit 1
VGNC:42004
475954
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inner mitochondrial membrane peptidase subunit 1
Macaque
inner mitochondrial membrane peptidase subunit 1
Mouse
Rat
Dog
inner mitochondrial membrane peptidase subunit 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96LU5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (62)
1 – 10 of 62
FAM117B
Tdark
Novelty:  1.06316483
p_int:  0.999998946
p_ni:  6.5e-7
p_wrong:  4.04e-7
Score:  0.345
Data Source:  BioPlex,STRINGDB
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.999988855
p_ni:  2.4e-7
p_wrong:  0.000010905
Score:  0.189
Data Source:  BioPlex,STRINGDB
CA6
Tclin
Family:  Enzyme
Novelty:  0.00293722
p_int:  0.999818441
p_ni:  0.000006875
p_wrong:  0.000174684
Data Source:  BioPlex
MPPED2
Tbio
Family:  Enzyme
Novelty:  0.091909
Score:  0.826
Data Source:  STRINGDB
RCN1
Tbio
Novelty:  0.00857135
Score:  0.795
Data Source:  STRINGDB
DNAJC24
Tbio
Novelty:  0.09398707
Score:  0.785
Data Source:  STRINGDB
ELP4
Tbio
Novelty:  0.03734233
Score:  0.767
Data Source:  STRINGDB
DCDC1
Tbio
Novelty:  0.21703566
Score:  0.754
Data Source:  STRINGDB
DCDC5
Tdark
Novelty:  0.21703566
Score:  0.754
Data Source:  STRINGDB
FBXO47
Tdark
Novelty:  0.26075359
Score:  0.744
Data Source:  STRINGDB
Publication Statistics
PubMed Score  6.86

PubMed score by year
PubTator Score  1.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer