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Tbio
RNPC3
RNA-binding region-containing protein 3

Protein Summary
Description
Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA. Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 65K protein that is a component of the U12-type spliceosome. This protein contains two RNA recognition motifs (RRMs), suggesting that it may contact one of the small nuclear RNAs of the minor spliceosome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423855
  • ENSP00000391432
  • ENSG00000185946
  • ENST00000524631
  • ENSP00000437278
  • ENST00000533099
  • ENSP00000432886

Symbol
  • KIAA1839
  • RBM40
  • RNP
  • SNRNP65
  • RNP
  • IGHD5
  • RBM40
  • SNRNP65
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
histone modification site profile
0.76
cell type or tissue
0.59
interacting protein
0.55
tissue sample
0.55


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.59   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.59   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding region (RNP1, RRM) containing 3
469395
Macaque
RNA binding region (RNP1, RRM) containing 3
717115
Mouse
MGI:1914475
67225
Rat
RGD:1582776
691538
Dog
RNA binding region (RNP1, RRM) containing 3
490136
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding region (RNP1, RRM) containing 3
Macaque
RNA binding region (RNP1, RRM) containing 3
Mouse
Rat
Dog
RNA binding region (RNP1, RRM) containing 3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96LT9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Minor Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Minor Pathway
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (150)
1 – 10 of 150
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.999999692
p_ni:  3.08e-7
Score:  0.891
Data Source:  BioPlex,STRINGDB
PHF5A
Tbio
Family:  Epigenetic
Novelty:  0.02989472
p_int:  0.999999161
p_ni:  8.31e-7
p_wrong:  8e-9
Score:  0.973
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.999998421
p_ni:  0.000001579
Data Source:  BioPlex
ZRSR2
Tbio
Novelty:  0.03449891
p_int:  0.999997498
p_ni:  0.000002501
Score:  0.993
Data Source:  BioPlex,STRINGDB
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.999995605
p_ni:  0.000004394
Score:  0.967
Data Source:  BioPlex,STRINGDB
ZCRB1
Tdark
Novelty:  0.37592387
p_int:  0.999992285
p_ni:  0.000007715
Score:  0.975
Data Source:  BioPlex,STRINGDB
P4HA1
Tchem
Family:  Enzyme
Novelty:  0.01624726
p_int:  0.999983219
p_ni:  0.000016781
Data Source:  BioPlex
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999957643
p_ni:  0.000042356
p_wrong:  1e-9
Score:  0.99
Data Source:  BioPlex,STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.999955862
p_ni:  0.000044138
Score:  0.989
Data Source:  BioPlex,STRINGDB
ZMAT5
Tdark
Novelty:  0.97115324
p_int:  0.999924881
p_ni:  0.000075044
p_wrong:  7.6e-8
Score:  0.992
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  17.59

PubMed score by year
PubTator Score  391.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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