Tbio RNPC3 RNA-binding region-containing protein 3

Protein Summary

Description

Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA. Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 65K protein that is a component of the U12-type spliceosome. This protein contains two RNA recognition motifs (RRMs), suggesting that it may contact one of the small nuclear RNAs of the minor spliceosome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96LT9
• A8K1C9
• D3DT74
• Q5TZ87
• Q96FK7
• Q96JI8
• Q9NSU7
• Q9NXX2

Gene Name

• RNPC3

Ensembl ID

• ENST00000423855
• ENSP00000391432
• ENSG00000185946
• ENST00000524631
• ENSP00000437278
• ENST00000533099
• ENSP00000432886

Symbol

• KIAA1839
• RBM40
• RNP
• SNRNP65
• RNP
• IGHD5
• RBM40
• SNRNP65

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
histone modification site profile	0.76
cell type or tissue	0.59
interacting protein	0.55
tissue sample	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.81   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 79   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.81   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0