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Tdark
PPP1R36
Protein phosphatase 1 regulatory subunit 36

Protein Summary
Description
Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298705
  • ENSP00000298705
  • ENSG00000165807

Symbol
  • C14orf50
  • C14orf50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.75
tissue sample
0.68
phenotype
0.6
cell type or tissue
0.56
histone modification site profile
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.19   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.19   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (12)
CCDC125
Tbio
Novelty:  0.66782281
Score:  0.669
Data Source:  STRINGDB
VWA7
Tdark
Novelty:  0.15513587
Score:  0.57
Data Source:  STRINGDB
MED11
Tdark
Family:  Enzyme
Novelty:  0.11467738
Score:  0.559
Data Source:  STRINGDB
TRAPPC12
Tbio
Novelty:  0.09847363
Score:  0.544
Data Source:  STRINGDB
PIMREG
Tbio
Novelty:  0.02575266
Score:  0.532
Data Source:  STRINGDB
FOXS1
Tbio
Family:  TF
Novelty:  0.17661517
Score:  0.53
Data Source:  STRINGDB
ARFRP1
Tbio
Family:  Enzyme
Novelty:  0.07011092
Score:  0.473
Data Source:  STRINGDB
SPATA33
Tdark
Novelty:  0.36605573
Score:  0.454
Data Source:  STRINGDB
KRT86
Tbio
Novelty:  0.01021995
Score:  0.45
Data Source:  STRINGDB
CXCL17
Tbio
Novelty:  0.0333432
Score:  0.424
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
4
4
87.6
lymphocyte percentage of leukocytes
2
2
2
79.3
neutrophil percentage of leukocytes
1
1
1
61.3
educational attainment
1
1
1
61.2
heel bone mineral density
1
1
1
52.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
87.6
lymphocyte percentage of leukocytes
2
79.3
neutrophil percentage of leukocytes
1
61.3
educational attainment
1
61.2
heel bone mineral density
1
52.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 36
VGNC:3354
452967
Macaque
protein phosphatase 1 regulatory subunit 36
707793
Mouse
MGI:2684916
210762
Rat
RGD:1309051
299153
Dog
protein phosphatase 1 regulatory subunit 36
VGNC:44894
611452
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 36
Macaque
protein phosphatase 1 regulatory subunit 36
Mouse
Rat
Dog
protein phosphatase 1 regulatory subunit 36
Publication Statistics
PubMed Score 1.19
PubMed score by year
PubTator Score 0.41
PubTator score by year
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Related Publications
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PMID
Year
Title