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Tbio
CEP19
Centrosomal protein of 19 kDa

Protein Summary
Description
Required for ciliation (PubMed:28625565, PubMed:28428259, PubMed:28659385). Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia (PubMed:28625565, PubMed:28428259). Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes (PubMed:28659385). The protein encoded by this gene localizes to centrosomes and primary cilia and co-localizes with a marker for the mother centriole. This gene resides in a region of human chromosome 3 that is linked to morbid obesity. A homozygous knockout of the orthologous gene in mouse resulted in mice with morbid obesity, hyperphagy, glucose i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409690
  • ENSP00000387209
  • ENSG00000174007

Symbol
  • C3orf34
  • MOSPGF
  • C3orf34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
histone modification site profile
0.91
tissue sample
0.69
cellular component
0.65
cell type or tissue
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.02   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.02   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
PPP2R3C
Tbio
Family:  Enzyme
Novelty:  0.02970644
p_int:  0.999999995
p_ni:  3e-9
p_wrong:  2e-9
Data Source:  BioPlex
CEP350
Tbio
Novelty:  0.09063779
p_int:  0.999999989
p_ni:  1.1e-8
Score:  0.594
Data Source:  BioPlex,STRINGDB
SMARCAD1
Tbio
Novelty:  0.04117162
p_int:  0.999998977
p_ni:  0.000001023
Data Source:  BioPlex
FMN2
Tbio
Novelty:  0.02031944
p_int:  0.999998186
p_ni:  0.000001814
Data Source:  BioPlex
RABL2A
Tbio
Family:  Enzyme
Novelty:  0.09940618
p_int:  0.99945384
p_ni:  0.000139531
p_wrong:  0.000406628
Score:  0.638
Data Source:  BioPlex,STRINGDB
FGFR1OP
Tbio
Novelty:  0.09922864
p_int:  0.999452025
p_ni:  4.3e-8
p_wrong:  0.000547932
Score:  0.863
Data Source:  BioPlex,STRINGDB
MCM5
Tbio
Novelty:  0.00716583
p_int:  0.978203576
p_ni:  0.021796424
Data Source:  BioPlex
MCM3
Tbio
Novelty:  0.00593382
p_int:  0.95518566
p_ni:  0.04481434
Data Source:  BioPlex
PPP2R1B
Tbio
Family:  Enzyme
Novelty:  0.03936638
p_int:  0.867079499
p_ni:  0.132920499
p_wrong:  2e-9
Data Source:  BioPlex
RABL2B
Tdark
Family:  Enzyme
Novelty:  0.16730643
Score:  0.8
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
2
3
94.3
leukocyte count
2
2
2
93.3
platelet crit
2
2
2
92.2
eosinophil count
3
3
4
89.5
platelet count
2
2
2
87
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
94.3
leukocyte count
2
93.3
platelet crit
2
92.2
eosinophil count
4
89.5
platelet count
2
87
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 19
VGNC:1772
743652
Macaque
centrosomal protein 19
710498
Mouse
MGI:1914244
66994
Rat
RGD:621352
192229
Dog
centrosomal protein 19
VGNC:39123
609577
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 19
Macaque
centrosomal protein 19
Mouse
Rat
Dog
centrosomal protein 19
Publication Statistics
PubMed Score 5.02
PubMed score by year
PubTator Score 2.89
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title