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Tchem
SENP8
Sentrin-specific protease 8

Protein Summary
Description
Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340912
  • ENSP00000340505
  • ENSG00000166192
  • ENST00000542035
  • ENSP00000446057

Symbol
  • DEN1
  • NEDP1
  • PRSC2
  • DEN1
  • NEDP1
  • PRSC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.63
tissue sample
0.61
cell line
0.55
tissue
0.46
gene perturbation
0.4


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.53   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.53   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
73.6
aspartate aminotransferase measurement
1
1
0
5.9
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
73.6
aspartate aminotransferase measurement
0
5.9
30.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SUMO/sentrin peptidase family member, NEDD8 specific
697613
Mouse
MGI:1918849
71599
Rat
RGD:1309955
315723
Dog
SUMO peptidase family member, NEDD8 specific
VGNC:46008
487631
Horse
SUMO peptidase family member, NEDD8 specific
VGNC:22826
100052291
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SUMO/sentrin peptidase family member, NEDD8 specific
Mouse
Rat
Dog
SUMO peptidase family member, NEDD8 specific
Horse
SUMO peptidase family member, NEDD8 specific
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96LD8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Reactome
UCH proteinases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Neddylation
Post-translational protein modification
UCH proteinases
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (57)
1 – 10 of 57
IFT43
Tbio
Novelty:  0.00478274
p_int:  0.999191507
p_ni:  0.000808492
p_wrong:  1e-9
Score:  0.332
Data Source:  BioPlex,STRINGDB
HDGFL3
Tbio
Family:  Epigenetic
Novelty:  0.14292821
p_int:  0.972853774
p_ni:  0.025692431
p_wrong:  0.001453794
Score:  0.309
Data Source:  BioPlex,STRINGDB
NEDD8
Tchem
Novelty:  0.00305343
Score:  0.999
Data Source:  Reactome,STRINGDB
UCHL3
Tchem
Family:  Enzyme
Novelty:  0.01206871
Score:  0.984
Data Source:  STRINGDB
NAE1
Tchem
Novelty:  0.0283623
Score:  0.969
Data Source:  STRINGDB
UBA3
Tchem
Novelty:  0.03962261
Score:  0.967
Data Source:  STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.843
Data Source:  STRINGDB
COPS5
Tchem
Novelty:  0.00406225
Score:  0.818
Data Source:  STRINGDB
CUL4A
Tchem
Novelty:  0.00917788
Score:  0.814
Data Source:  STRINGDB
SENP6
Tchem
Family:  Enzyme
Novelty:  0.00776149
Score:  0.784
Data Source:  STRINGDB
Publication Statistics
PubMed Score  130.53

PubMed score by year
PubTator Score  167.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer