Tbio BMF Bcl-2-modifying factor

Protein Summary

Description

May play a role in apoptosis. Isoform 1 seems to be the main initiator. The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96LC9
• Q2M396
• Q6NT30
• Q6NT56
• Q6P9F6
• Q7Z7D4
• Q7Z7D5
• Q9H7K7

Gene Name

• BMF

Ensembl ID

• ENST00000354670
• ENSP00000346697
• ENSG00000104081
• ENST00000397573
• ENSP00000380703
• ENST00000431415
• ENSP00000396511
• ENST00000558774
• ENSP00000453913
• ENST00000559701
• ENSP00000453919
• ENST00000561282
• ENSP00000453522
• ENST00000561360
• ENSP00000453892

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.93
transcription factor	0.77
PubMedID	0.68
cellular component	0.64
biological process	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.35   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 417   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.35   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0