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Tbio
PGLYRP3
Peptidoglycan recognition protein 3

Protein Summary
Description
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity. This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290722
  • ENSP00000290722
  • ENSG00000159527

Symbol
  • PGRPIA
  • PGRPIA
  • PGRP-Ialpha
  • PGLYRPIalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
biological process
0.72
tissue sample
0.58
cell line
0.51
tissue
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.27   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.27   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Gene Ontology Terms (21)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (28)
1 – 10 of 28
DHTKD1
Tbio
Family: Enzyme
Novelty: 0.0381406
p_int: 0.999998162
p_ni: 0.000001777
p_wrong: 6.1e-8
Score: 0.513
Data Source: BioPlex,STRINGDB
MICA
Tbio
Novelty: 0.03965901
p_int: 0.822684097
p_ni: 0.177313664
p_wrong: 0.000002239
Score: 0.237
Data Source: BioPlex,STRINGDB
PGLYRP4
Tbio
Novelty: 0.09046504
Score: 0.935
Data Source: Reactome,STRINGDB
LCE1A
Tbio
Novelty: 0.04596696
Score: 0.744
Data Source: STRINGDB
SPG7
Tbio
Family: Enzyme
Novelty: 0.00463357
Score: 0.743
Data Source: STRINGDB
LCE3B
Tbio
Novelty: 0.05400263
Score: 0.741
Data Source: STRINGDB
LCE3C
Tbio
Novelty: 0.04910233
Score: 0.722
Data Source: STRINGDB
CRNN
Tbio
Novelty: 0.01648731
Score: 0.647
Data Source: STRINGDB
PRSS27
Tbio
Family: Enzyme
Novelty: 0.03862089
Score: 0.622
Data Source: STRINGDB
IVL
Tbio
Novelty: 0.00147892
Score: 0.612
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.27

PubMed score by year
PubTator Score  10.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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