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Tbio
ATP6V1G3
V-type proton ATPase subunit G 3

Protein Summary
Description
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes on ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281087
  • ENSP00000281087
  • ENSG00000151418
  • ENST00000309309
  • ENSP00000309574
  • ENST00000367381
  • ENSP00000356351
  • ENSG00000263014
  • ENST00000367382
  • ENSP00000356352
  • ENST00000489986
  • ENSP00000417171
  • ENST00000571439
  • ENSP00000461616
  • ENST00000573121
  • ENSP00000461329
  • ENST00000575971
  • ENSP00000461228

Symbol
  • ATP6G3
  • Vma10
  • ATP6G3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
tissue
0.53
biological process
0.5
virus perturbation
0.5
metabolite
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.66   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.66   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (56)
Items per page:
1 – 5 of 56
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
4
3
4
88.7
mean corpuscular hemoglobin concentration
4
3
4
88.7
mean corpuscular volume
3
2
3
84.9
mean corpuscular volume
3
2
3
84.9
mean corpuscular hemoglobin
2
2
2
83.9
Items per page:
1 – 5 of 56
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
4
88.7
mean corpuscular hemoglobin concentration
4
88.7
mean corpuscular volume
3
84.9
mean corpuscular volume
3
84.9
mean corpuscular hemoglobin
2
83.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ATPase H+ transporting V1 subunit G3
710372
Mouse
MGI:2450548
338375
Rat
RGD:1304635
289407
Dog
ATPase H+ transporting V1 subunit G3
VGNC:38283
490256
Cow
ATPase H+ transporting V1 subunit G3
VGNC:26325
613925
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ATPase H+ transporting V1 subunit G3
Mouse
Rat
Dog
ATPase H+ transporting V1 subunit G3
Cow
ATPase H+ transporting V1 subunit G3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96LB4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Protein-Protein Interactions (74)
1 – 10 of 74
MTMR4
Tbio
Family:  Enzyme
Novelty:  0.09166984
p_int:  0.826715504
p_ni:  0.068141071
p_wrong:  0.105143425
Score:  0.269
Data Source:  BioPlex,STRINGDB
ATP6V1F
Tbio
Family:  Enzyme
Novelty:  0.07109314
Score:  0.996
Data Source:  STRINGDB
ATP6V1D
Tbio
Family:  Enzyme
Novelty:  0.02298626
Score:  0.994
Data Source:  STRINGDB
ATP6V1E2
Tbio
Family:  Enzyme
Novelty:  0.10447007
Score:  0.994
Data Source:  STRINGDB
ATP6V1H
Tbio
Family:  Enzyme
Novelty:  0.04269105
Score:  0.994
Data Source:  STRINGDB
ATP6V1E1
Tbio
Family:  Enzyme
Novelty:  0.04832113
Score:  0.993
Data Source:  STRINGDB
ATP6V1C2
Tbio
Family:  Enzyme
Novelty:  0.07583427
Score:  0.99
Data Source:  STRINGDB
ATP6V0D2
Tbio
Family:  Enzyme
Novelty:  0.0354396
Score:  0.989
Data Source:  STRINGDB
ATP6V0D1
Tbio
Family:  Enzyme
Novelty:  0.05146108
Score:  0.989
Data Source:  STRINGDB
ATP6V1B1
Tchem
Family:  Enzyme
Novelty:  0.01122589
Score:  0.989
Data Source:  STRINGDB
Publication Statistics
PubMed Score  7.66

PubMed score by year
PubTator Score  2.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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