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Tbio
IFT74
Intraflagellar transport protein 74 homolog

Protein Summary
Description
Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis. This gene encodes a core intraflagellar transport (IFT) protein which belongs to a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT proteins are found at the base of the cilium as well as inside the cilium, where they assemble into long arrays between the ciliary base and tip. This protein, together with intraflagellar transport protein 81, binds and transports tubulin within cilia and is required for ciliogenesis. Naturally occurring mutations in this gene are associated with amyotrophic lateral sclerosis--frontotemporal dementia and Bardet-Biedl Syndrome. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380062
  • ENSP00000369402
  • ENSG00000096872
  • ENST00000429045
  • ENSP00000393907
  • ENST00000433700
  • ENSP00000389224
  • ENST00000443698
  • ENSP00000404122

Symbol
  • CCDC2
  • CMG1
  • CMG1
  • BBS20
  • CCDC2
  • CMG-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
cellular component
0.69
cell line
0.68
tissue sample
0.67
biological process
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.9   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.9   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
IFT81
Tbio
Novelty:  0.01610195
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
TTC30A
Tdark
Novelty:  1.41742212
p_int:  0.999998421
p_ni:  0.000001579
Score:  0.995
Data Source:  BioPlex,STRINGDB
SIGLEC7
Tchem
Novelty:  0.01496432
p_int:  0.999998414
p_ni:  0.000001116
p_wrong:  4.7e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
IFT27
Tbio
Family:  Enzyme
Novelty:  0.05592902
p_int:  0.999998211
p_ni:  0.000001789
Score:  0.989
Data Source:  BioPlex,STRINGDB
TTC30B
Tbio
Novelty:  0.10944566
p_int:  0.999996787
p_ni:  0.000003213
Score:  0.996
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999993844
p_ni:  0.000006156
Data Source:  BioPlex
IFT57
Tbio
Novelty:  0.03373199
p_int:  0.999935207
p_ni:  0.000064793
Score:  0.996
Data Source:  BioPlex,STRINGDB
ARL13B
Tbio
Family:  Enzyme
Novelty:  0.01481674
p_int:  0.99986162
p_ni:  0.00013838
Score:  0.915
Data Source:  BioPlex,STRINGDB
TSPYL4
Tdark
Novelty:  0.4538252
p_int:  0.999860605
p_ni:  0.000139395
Score:  0.179
Data Source:  BioPlex,STRINGDB
ANKRD55
Tbio
Novelty:  0.09730833
p_int:  0.999808991
p_ni:  0.000191009
Score:  0.838
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (25)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Intraflagellar transport
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
82.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
82.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
intraflagellar transport 74
VGNC:4762
465027
Macaque
intraflagellar transport 74
707561
Mouse
MGI:1914944
67694
Rat
RGD:1359704
313365
Dog
intraflagellar transport 74
VGNC:41890
474734
Species
Name
OMA
EggNOG
Inparanoid
Chimp
intraflagellar transport 74
Macaque
intraflagellar transport 74
Mouse
Rat
Dog
intraflagellar transport 74
Publication Statistics
PubMed Score 18.90
PubMed score by year
PubTator Score 9.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title