Tbio IFT74 Intraflagellar transport protein 74 homolog

Protein Summary

Description

Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis. This gene encodes a core intraflagellar transport (IFT) protein which belongs to a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT proteins are found at the base of the cilium as well as inside the cilium, where they assemble into long arrays between the ciliary base and tip. This protein, together with intraflagellar transport protein 81, binds and transports tubulin within cilia and is required for ciliogenesis. Naturally occurring mutations in this gene are associated with amyotrophic lateral sclerosis--frontotemporal dementia and Bardet-Biedl Syndrome. [provided by RefSeq, Mar 2017]

Uniprot Accession IDs

• Q96LB3
• Q3B789
• Q5VY34
• Q6PGQ8
• Q9H643
• Q9H8G7

Gene Name

• IFT74

Ensembl ID

• ENST00000380062
• ENSP00000369402
• ENSG00000096872
• ENST00000429045
• ENSP00000393907
• ENST00000433700
• ENSP00000389224
• ENST00000443698
• ENSP00000404122

Symbol

• CCDC2
• CMG1
• CMG1
• BBS20
• CCDC2
• CMG-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.86
cellular component	0.69
cell line	0.68
tissue sample	0.67
biological process	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.76   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 172   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.76   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0