Tbio MRGPRX3 Mas-related G-protein coupled receptor member X3

Protein Summary

Description

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity). This gene encodes a member of the mas-related/sensory neuron specific subfamily of G protein coupled receptors. The encoded protein may be involved in sensory neuron regulation and in the modulation of pain. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q96LB0
• B0M0L1
• Q8TDE0
• Q8TDE1

Gene Name

• MRGPRX3

Ensembl ID

• ENST00000396275
• ENSP00000379571
• ENSG00000179826
• ENST00000621697
• ENSP00000481943

Symbol

• MRGX3
• SNSR1
• SNSR2
• GPCR
• MRGX3
• SNSR1
• SNSR2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.54
tissue	0.51
gene perturbation	0.5
virus perturbation	0.45
cell line	0.44

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Mas Proto-oncogene And Mas-related (Mrgs) Receptor / Mas-related G-protein Coupled Receptor Member X3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.12   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.12   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0