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Tchem
PRMT6
Protein arginine N-methyltransferase 6

Protein Summary
Description
Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910). Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910). Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (PubMed:17898714, PubMed:18079182, PubMed:18077460). H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (PubMed:17898714, PubMed:18077460). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:19509293). Repression of TP53 blocks cellular senescence (By similarity). Also methylates ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370078
  • ENSP00000359095
  • ENSG00000198890

Symbol
  • HRMT1L6
  • HRMT1L6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.76
cell type or tissue
0.72
molecular function
0.7
transcription factor binding site profile
0.69
virus perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.65   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 353   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.65   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 353   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 58
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (58)
1 – 10 of 58
CHEMBL3901808
chemical structure image
CHEMBL3961701
chemical structure image
CHEMBL3970878
chemical structure image
CHEMBL3589040
chemical structure image
CHEMBL3589043
chemical structure image
CHEMBL3589039
chemical structure image
CHEMBL3589042
chemical structure image
CHEMBL3589035
chemical structure image
CHEMBL3589912
chemical structure image
CHEMBL3590417
chemical structure image
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
99.5
testosterone measurement
2
2
2
96.3
lifestyle measurement
1
1
1
58.1
low density lipoprotein cholesterol measurement
2
1
2
27.4
body mass index
1
1
1
22.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
99.5
testosterone measurement
2
96.3
lifestyle measurement
1
58.1
low density lipoprotein cholesterol measurement
2
27.4
body mass index
1
22.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein arginine methyltransferase 6
VGNC:6962
457073
Macaque
protein arginine methyltransferase 6
694284
Mouse
MGI:2139971
99890
Dog
protein arginine methyltransferase 6
VGNC:44999
490133
Horse
protein arginine methyltransferase 6
VGNC:21863
100060260
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein arginine methyltransferase 6
Macaque
protein arginine methyltransferase 6
Mouse
Dog
protein arginine methyltransferase 6
Horse
protein arginine methyltransferase 6
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96LA8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RMTs methylate histone arginines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
RMTs methylate histone arginines
Gene Ontology Terms (27)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CACAO
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (200)
1 – 10 of 200
UBP1
Tbio
Family: TF
Novelty: 0.01140885
p_int: 0.999287909
p_ni: 0.000348554
p_wrong: 0.000363538
Score: 0.752
Data Source: BioPlex,STRINGDB
TFCP2
Tbio
Family: TF
Novelty: 0.00687548
p_int: 0.999175525
p_ni: 0.000824475
Score: 0.563
Data Source: BioPlex,STRINGDB
PPP1R1A
Tbio
Family: Enzyme
Novelty: 0.01565981
p_int: 0.996389898
p_ni: 0.002946775
p_wrong: 0.000663327
Score: 0.183
Data Source: BioPlex,STRINGDB
SEC23IP
Tbio
Novelty: 0.0925721
p_int: 0.994691737
p_ni: 0.005308263
Score: 0.239
Data Source: BioPlex,STRINGDB
ILF2
Tbio
Novelty: 0.01598188
p_int: 0.989199208
p_ni: 0.010800764
p_wrong: 2.8e-8
Score: 0.282
Data Source: BioPlex,STRINGDB
IGF2
Tbio
Novelty: 0.00021277
p_int: 0.98584594
p_ni: 0.014154059
Data Source: BioPlex
CIRBP
Tbio
Novelty: 0.00439066
p_int: 0.979151038
p_ni: 0.020835581
p_wrong: 0.000013381
Score: 0.196
Data Source: BioPlex,STRINGDB
ZFC3H1
Tbio
Novelty: 0.17313739
p_int: 0.978995008
p_ni: 0.021004992
Data Source: BioPlex
DDX23
Tbio
Family: Enzyme
Novelty: 0.03592096
p_int: 0.978541161
p_ni: 0.021458839
Score: 0.219
Data Source: BioPlex,STRINGDB
DNAJC12
Tbio
Novelty: 0.05214775
p_int: 0.978428465
p_ni: 0.021571532
p_wrong: 3e-9
Score: 0.169
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  74.65

PubMed score by year
PubTator Score  46.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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