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Tbio
FCRL1
Fc receptor-like protein 1

Protein Summary
Description
May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358292
  • ENSP00000351039
  • ENSG00000163534
  • ENST00000368176
  • ENSP00000357158
  • ENST00000491942
  • ENSP00000418130

Symbol
  • FCRH1
  • IFGP1
  • IRTA5
  • FCRH1
  • IFGP1
  • IRTA5
  • CD307a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.62
microRNA
0.62
disease
0.54
cell type or tissue
0.52
tissue
0.48


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.01   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.01   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
68.5
1
1
0
1.2
58.4
2
2
1
1.1
29
autoantibody measurement
1
1
0
1.4
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
68.5
0
1.2
58.4
1
1.1
29
autoantibody measurement
0
1.4
6.1
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fc receptor like 1
VGNC:6820
469521
Macaque
Fc receptor like 1
718841
Mouse
MGI:2442862
229499
Rat
RGD:1589411
680665
Dog
Fc receptor-like protein 1
612035
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fc receptor like 1
Macaque
Fc receptor like 1
Mouse
Rat
Dog
Fc receptor-like protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96LA6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (24)
1 – 10 of 24
APOD
Tbio
Novelty:  0.0031899
p_int:  0.753056569
p_ni:  0.246925772
p_wrong:  0.000017658
Score:  0.319
Data Source:  BioPlex,STRINGDB
PIGR
Tbio
Novelty:  0.0025812
Score:  0.753
Data Source:  STRINGDB
FCGR1A
Tclin
Novelty:  0.00073204
Score:  0.718
Data Source:  STRINGDB
FCGR3A
Tclin
Novelty:  0.0004214
Score:  0.65
Data Source:  STRINGDB
FCGR2B
Tbio
Novelty:  0.00098166
Score:  0.575
Data Source:  STRINGDB
FCRLB
Tbio
Novelty:  0.07161168
Score:  0.559
Data Source:  STRINGDB
FOXB2
Tdark
Family:  TF
Novelty:  0.40241439
Score:  0.545
Data Source:  STRINGDB
RGS20
Tbio
Novelty:  0.04087618
Score:  0.538
Data Source:  STRINGDB
NLRP10
Tbio
Novelty:  0.0472395
Score:  0.518
Data Source:  STRINGDB
TMPRSS4
Tbio
Family:  Enzyme
Novelty:  0.01429547
Score:  0.516
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.01

PubMed score by year
PubTator Score  17.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer