FCRL2
Fc receptor-like protein 2
Protein Summary
May have an regulatory role in normal and neoplastic B cell development. This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Apr 2009]
- ENST00000361516
- ENSP00000355157
- ENSG00000132704
- ENST00000368181
- ENSP00000357163
- ENST00000469986
- ENSP00000417393
- FCRH2
- IFGP4
- IRTA4
- SPAP1
- FCRH2
- IFGP4
- IRTA4
- SPAP1
- CD307b
- SPAP1A
- SPAP1B
- SPAP1C
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.95 | ||
protein domain | 0.58 | ||
cell line | 0.47 | ||
gene perturbation | 0.46 | ||
kinase perturbation | 0.42 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.78 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 107 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.78 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 107 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0