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Tdark
ALPK3
Alpha-protein kinase 3

Protein Summary
Description
Involved in cardiomyocyte differentiation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258888
  • ENSP00000258888
  • ENSG00000136383

Symbol
  • KIAA1330
  • MAK
  • MAK
  • CMH27
  • MIDORI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
protein domain
0.85
kinase perturbation
0.81
interacting protein
0.72
tissue sample
0.62


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.49   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.49   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
68
P wave terminal force measurement
1
2
0
85.5
58
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
68
P wave terminal force measurement
0
85.5
58
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alpha kinase 3
VGNC:1569
453609
Macaque
alpha kinase 3
695110
Mouse
MGI:2151224
116904
Rat
RGD:1309860
365298
Dog
alpha kinase 3
VGNC:37817
479052
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alpha kinase 3
Macaque
alpha kinase 3
Mouse
Rat
Dog
alpha kinase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96L96-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (22)
1 – 10 of 22
EIF2AK3
Tchem
Family: Kinase
Novelty: 0.00044559
Score: 0.754
Data Source: STRINGDB
PAX4
Tbio
Family: TF
Novelty: 0.00697085
Score: 0.711
Data Source: STRINGDB
PRSS54
Tdark
Family: Enzyme
Novelty: 0.4382869
Score: 0.672
Data Source: STRINGDB
ALPK1
Tbio
Family: Kinase
Novelty: 0.04419259
Score: 0.587
Data Source: STRINGDB
C1orf167
Tdark
Novelty: 1.10306407
Score: 0.587
Data Source: STRINGDB
OR5C1
Tdark
Family: oGPCR
Novelty: 1.6529517
Score: 0.585
Data Source: STRINGDB
WDR25
Tdark
Novelty: 0.53632123
Score: 0.579
Data Source: STRINGDB
ZNF592
Tbio
Novelty: 0.12109299
Score: 0.555
Data Source: STRINGDB
GPR25
Tdark
Family: GPCR
Novelty: 0.42142701
Score: 0.514
Data Source: STRINGDB
ABCC6
Tbio
Family: Transporter
Novelty: 0.0032341
Score: 0.496
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.49

PubMed score by year
PubTator Score  11.33

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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