Protein Summary
Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associat ...more
- ENST00000368843
- ENSP00000357836
- ENSG00000143376
- ENST00000458013
- ENSP00000400333
- KIAA0488
- MRT1
- MY014
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.79 | ||
interacting protein | 0.74 | ||
protein domain | 0.73 | ||
kinase perturbation | 0.71 | ||
disease perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 57.54 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 246 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 57.54 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 246 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (150)
CDS1
Family: Enzyme
Novelty: 0.08094799
p_int: 0.999997523
p_ni: 0.000002477
Data Source: BioPlex
CP
Novelty: 0.00103285
p_int: 0.999995688
p_ni: 0.000004301
p_wrong: 1.1e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
BPIFA1
Novelty: 0.00586117
p_int: 0.999982239
p_ni: 0.000011377
p_wrong: 0.000006384
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (2)
Components (6)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
vitamin D measurement | 1 | 2 | 2 | 77.1 | |||||
6 | 3 | 4 | 1.1 | 66.5 | |||||
hematocrit | 1 | 1 | 1 | 48.5 | |||||
apolipoprotein A 1 measurement | 1 | 1 | 1 | 45.2 | |||||
1 | 1 | 0 | 1.2 | 42.3 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
vitamin D measurement | 2 | 77.1 | |||||
4 | 1.1 | 66.5 | |||||
hematocrit | 1 | 48.5 | |||||
apolipoprotein A 1 measurement | 1 | 45.2 | |||||
0 | 1.2 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | sorting nexin family member 27 | VGNC:10986 | 457299 | |||||
Macaque | sorting nexin family member 27 | 710990 | ||||||
Mouse | MGI:1923992 | 76742 | ||||||
Rat | RGD:628705 | 260323 | ||||||
Dog | sorting nexin family member 27 | VGNC:46634 | 483200 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | sorting nexin family member 27 | |||||
Macaque | sorting nexin family member 27 | |||||
Mouse | ||||||
Rat | ||||||
Dog | sorting nexin family member 27 | |||||
Publication Statistics
PubMed Score 57.54
PubMed score by year
PubTator Score 43.56
PubTator score by year
Related Publications
Text Mined References (40)
GeneRif Annotations (29)
Items per page:
0 of 0
PMID | Year | Title |
|---|