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Tbio
EP400
E1A-binding protein p400

Protein Summary
Description
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389561
  • ENSP00000374212
  • ENSG00000183495
  • ENST00000389562
  • ENSP00000374213

Symbol
  • CAGH32
  • KIAA1498
  • KIAA1818
  • TNRC12
  • P400
  • CAGH32
  • TNRC12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.96
disease perturbation
0.9
cellular component
0.81
kinase perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.88   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.88   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
2
4
87.1
mean corpuscular volume
1
2
2
76.6
2
2
2
47.5
mean reticulocyte volume
1
1
1
34.7
pulmonary function measurement
1
1
0
7.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
87.1
mean corpuscular volume
2
76.6
2
47.5
mean reticulocyte volume
1
34.7
pulmonary function measurement
0
7.1
21.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
E1A binding protein p400
VGNC:5365
452377
Macaque
E1A-binding protein p400
709936
Mouse
MGI:1276124
75560
Rat
RGD:1304733
304569
Dog
E1A binding protein p400
VGNC:40390
486227
Species
Name
OMA
EggNOG
Inparanoid
Chimp
E1A binding protein p400
Macaque
E1A-binding protein p400
Mouse
Rat
Dog
E1A binding protein p400
Protein Structure (0 Structures, 10 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Chromatin modifying enzymes
Chromatin organization
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (191)
1 – 10 of 191
FOXR2
Tbio
Family:  TF
Novelty:  0.06548862
p_int:  0.999998519
p_ni:  0.000001481
Score:  0.711
Data Source:  BioPlex,STRINGDB
MYCL
Tbio
Family:  TF
Novelty:  0.0034508
p_int:  0.999997088
p_ni:  0.000002912
Score:  0.785
Data Source:  BioPlex,STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
p_int:  0.99999651
p_ni:  0.00000349
Score:  0.996
Data Source:  BioPlex,STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
p_int:  0.999995748
p_ni:  0.000004252
Score:  0.945
Data Source:  BioPlex,STRINGDB
MORF4L2
Tbio
Novelty:  0.09897629
p_int:  0.999994409
p_ni:  0.000005591
Score:  0.981
Data Source:  BioPlex,STRINGDB
MEAF6
Tbio
Novelty:  0.0914094
p_int:  0.99999288
p_ni:  0.00000712
Score:  0.99
Data Source:  BioPlex,STRINGDB
RUVBL2
Tbio
Novelty:  0.01129017
p_int:  0.99999287
p_ni:  0.00000713
Score:  0.996
Data Source:  BioPlex,STRINGDB
MRGBP
Tbio
Novelty:  0.09537142
p_int:  0.99999262
p_ni:  0.00000738
Score:  0.995
Data Source:  BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999991217
p_ni:  0.000008783
Score:  0.6
Data Source:  BioPlex,STRINGDB
MORF4L1
Tbio
Family:  Epigenetic
Novelty:  0.01696001
p_int:  0.999989635
p_ni:  0.000010365
Score:  0.993
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  45.88

PubMed score by year
PubTator Score  73.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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