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Tbio
B3GALT6
Beta-1,3-galactosyltransferase 6

Protein Summary
Description
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues. The enzyme encoded by this intronless gene is a beta-1,3-galactosyltransferase found in the medial Golgi apparatus, where it catalyzes the transfer of galactose from UDP-galactose to substrates containing a terminal beta-linked galactose moiety. The encoded enzyme has a particular affinity for galactose-beta-1,4-xylose found in the linker region of glycosamines. This enzyme is required for glycosaminoglycan synthesis. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379198
  • ENSP00000368496
  • ENSG00000176022
  • ENST00000647651
  • ENSP00000496787

Symbol
  • EDSP2
  • EDSSPD2
  • SEMDJL1
  • beta3GalT6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
histone modification site profile
0.74
transcription factor binding site profile
0.71
pathway
0.69
disease perturbation
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.15   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.15   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
beta-1,3-galactosyltransferase 6
703713
Mouse
MGI:2152819
117592
Rat
RGD:1309558
298690
Dog
beta-1,3-galactosyltransferase 6
VGNC:53266
664717
Cow
beta-1,3-galactosyltransferase 6
VGNC:26375
522406
Species
Name
OMA
EggNOG
Inparanoid
Macaque
beta-1,3-galactosyltransferase 6
Mouse
Rat
Dog
beta-1,3-galactosyltransferase 6
Cow
beta-1,3-galactosyltransferase 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96L58-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Reactome
Disease
Reactome
Diseases associated with glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Disease
Diseases associated with glycosaminoglycan metabolism
Protein-Protein Interactions (76)
1 – 10 of 76
SCN3B
Tbio
Family: IC
Novelty: 0.0438123
p_int: 0.976701636
p_ni: 0.023298364
Data Source: BioPlex
PEX19
Tbio
Novelty: 0.00605342
p_int: 0.974704296
p_ni: 0.025295703
p_wrong: 1e-9
Data Source: BioPlex
PBXIP1
Tbio
Novelty: 0.15404864
p_int: 0.961353408
p_ni: 0.038646592
Data Source: BioPlex
SYNE4
Tbio
Novelty: 0.0739848
p_int: 0.955464707
p_ni: 0.044535292
p_wrong: 1e-9
Score: 0.169
Data Source: BioPlex,STRINGDB
EIF2B5
Tbio
Novelty: 0.0102209
p_int: 0.822879272
p_ni: 0.177120728
Data Source: BioPlex
KCNA10
Tclin
Family: IC
Novelty: 0.05708808
p_int: 0.794172457
p_ni: 0.205827543
Score: 0.187
Data Source: BioPlex,STRINGDB
B4GALT7
Tbio
Family: Enzyme
Novelty: 0.02175499
Score: 0.993
Data Source: STRINGDB
B3GAT3
Tbio
Family: Enzyme
Novelty: 0.0289834
Score: 0.985
Data Source: STRINGDB
GPC2
Tbio
Novelty: 0.02182363
Score: 0.937
Data Source: STRINGDB
SDC2
Tbio
Novelty: 0.00597758
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.15

PubMed score by year
PubTator Score  16.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer