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Tbio
LRR1
Leucine-rich repeat protein 1

Protein Summary
Description
May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298288
  • ENSP00000298288
  • ENSG00000165501
  • ENST00000318317
  • ENSP00000315628

Symbol
  • PPIL5
  • LRR-1
  • PPIL5
  • 4-1BBLRR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
kinase perturbation
0.84
transcription factor binding site profile
0.65
transcription factor perturbation
0.61
tissue sample
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.85   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.85   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (373)
1 – 10 of 373
COPS2
Tbio
Novelty: 0.09131066
p_int: 0.999999613
p_ni: 3.85e-7
p_wrong: 2e-9
Score: 0.968
Data Source: BioPlex,STRINGDB
COPS3
Tbio
Novelty: 0.07789318
p_int: 0.999999552
p_ni: 4.48e-7
Score: 0.973
Data Source: BioPlex,STRINGDB
RELL2
Tbio
Novelty: 0.65217391
p_int: 0.99999633
p_ni: 0.000003636
p_wrong: 3.4e-8
Data Source: BioPlex
ZBTB38
Tbio
Family: TF
Novelty: 0.05996881
p_int: 0.999989725
p_ni: 0.000010261
p_wrong: 1.4e-8
Score: 0.199
Data Source: BioPlex,STRINGDB
COPS6
Tbio
Novelty: 0.02901234
p_int: 0.999986458
p_ni: 0.000013539
p_wrong: 3e-9
Score: 0.974
Data Source: BioPlex,STRINGDB
COPS8
Tbio
Novelty: 0.05324769
p_int: 0.999985749
p_ni: 0.000013985
p_wrong: 2.66e-7
Score: 0.981
Data Source: BioPlex,STRINGDB
CUL2
Tbio
Novelty: 0.00892549
p_int: 0.999923359
p_ni: 0.000075943
p_wrong: 6.98e-7
Score: 0.968
Data Source: BioPlex,STRINGDB
VHL
Tchem
Family: Enzyme
Novelty: 0.00323188
Score: 0.954
Data Source: STRINGDB
BTBD1
Tbio
Novelty: 0.32684825
Score: 0.954
Data Source: STRINGDB
ELOC
Tbio
Novelty: 0.0146568
Score: 0.952
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.85

PubMed score by year
PubTator Score  14.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer