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Tbio
CAPNS2
Calpain small subunit 2

Protein Summary
Description
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000457326
  • ENSP00000400882
  • ENSG00000256812

Symbol
  • CSS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.54
tissue
0.53
molecular function
0.49
gene perturbation
0.47
metabolite
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.1   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.1   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
LIX1L
Tdark
Novelty:  0.5277858
p_int:  0.999999995
p_ni:  2e-9
p_wrong:  3e-9
Score:  0.507
Data Source:  BioPlex,STRINGDB
CAST
Tbio
Novelty:  0.00099404
p_int:  0.999999529
p_ni:  4.71e-7
Score:  0.98
Data Source:  BioPlex,Reactome,STRINGDB
CAPN1
Tchem
Novelty:  0.00252811
p_int:  0.999999364
p_ni:  6.36e-7
Score:  0.979
Data Source:  BioPlex,Reactome,STRINGDB
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.999662259
p_ni:  0.000085769
p_wrong:  0.000251973
Data Source:  BioPlex
NDUFS5
Tclin
Family:  Enzyme
Novelty:  0.13274675
p_int:  0.999654487
p_ni:  0.00028432
p_wrong:  0.000061193
Data Source:  BioPlex
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.999242426
p_ni:  0.000037596
p_wrong:  0.000719979
Data Source:  BioPlex
CCDC103
Tbio
Novelty:  0.07857649
p_int:  0.993724898
p_ni:  0.001883634
p_wrong:  0.004391468
Data Source:  BioPlex
RBFOX1
Tbio
Novelty:  0.00571285
p_int:  0.951908216
p_ni:  0.003767984
p_wrong:  0.044323799
Score:  0.177
Data Source:  BioPlex,STRINGDB
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.945895891
p_ni:  0.001627445
p_wrong:  0.052476665
Data Source:  BioPlex
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.929199111
p_ni:  0.070800889
Score:  0.151
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Degradation of the extracellular matrix (R-HSA-1474228)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Reactome
Disease
Reactome
Extracellular matrix organization
Reactome
Neurodegenerative Diseases
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Disease
Extracellular matrix organization
Neurodegenerative Diseases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
88.7
birth weight
1
1
1
40.7
hormone measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
88.7
birth weight
1
40.7
hormone measurement
1
14.2
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 2.10
PubMed score by year
PubTator Score 15.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title