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Tchem
MARK4
MAP/microtubule affinity-regulating kinase 4

Protein Summary
Description
Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Pho ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262891
  • ENSP00000262891
  • ENSG00000007047
  • ENST00000300843
  • ENSP00000300843

Symbol
  • KIAA1860
  • MARKL1
  • MARK4L
  • MARK4S
  • MARKL1
  • PAR-1D
  • MARKL1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.99
interacting protein
0.82
hub protein
0.71
tissue sample
0.65


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.8   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.8   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (38)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
5
5
98.7
mean platelet volume
4
3
5
94.7
2
9
0
7
94
monocyte count
3
3
3
92.7
family history of Alzheimer’s disease
1
7
0
7.2
92.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
5
98.7
mean platelet volume
5
94.7
0
7
94
monocyte count
3
92.7
family history of Alzheimer’s disease
0
7.2
92.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microtubule affinity regulating kinase 4
VGNC:7561
456123
Macaque
microtubule affinity regulating kinase 4
715346
Mouse
MGI:1920955
232944
Rat
RGD:1591792
680407
Dog
microtubule affinity regulating kinase 4
VGNC:43026
484449
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microtubule affinity regulating kinase 4
Macaque
microtubule affinity regulating kinase 4
Mouse
Rat
Dog
microtubule affinity regulating kinase 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96L34-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cilium Assembly
Organelle biogenesis and maintenance
Gene Ontology Terms (30)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (138)
1 – 10 of 138
RPIA
Tbio
Family: Enzyme
Novelty: 0.00968705
p_int: 0.958489705
p_ni: 0.040983526
p_wrong: 0.00052677
Score: 0.309
Data Source: BioPlex,STRINGDB
PSMC3
Tbio
Family: Enzyme
Novelty: 0.04026019
p_int: 0.812886403
p_ni: 0.000020022
p_wrong: 0.187093575
Data Source: BioPlex
MANSC1
Tdark
Novelty: 0.91681036
p_int: 0.811231253
p_ni: 0.000104462
p_wrong: 0.188664285
Score: 0.296
Data Source: BioPlex,STRINGDB
CEP97
Tbio
Novelty: 0.12709162
Score: 0.951
Data Source: STRINGDB
CCP110
Tbio
Novelty: 0.02399511
Score: 0.944
Data Source: STRINGDB
KIF24
Tbio
Novelty: 0.13497665
Score: 0.942
Data Source: STRINGDB
STK11
Tchem
Family: Kinase
Novelty: 0.00073247
Score: 0.941
Data Source: STRINGDB
ODF2
Tbio
Novelty: 0.03203587
Score: 0.938
Data Source: STRINGDB
TUBA4A
Tchem
Novelty: 0.00820546
Score: 0.934
Data Source: STRINGDB
OFD1
Tbio
Novelty: 0.01032841
Score: 0.934
Data Source: STRINGDB
Publication Statistics
PubMed Score  63.80

PubMed score by year
PubTator Score  31.57

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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