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Tdark
CAPZA3
F-actin-capping protein subunit alpha-3

Protein Summary
Description
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity). This gene encodes an actin capping protein, one of the F-actin capping protein alpha subunit family. The encoded protein is predominantly localized to the neck region of ejaculated sperm, other immunohistochemical signals were found in the tail and postacrosomal regions. The encoded protein may also form heterodimers of alpha and beta subunits. This protein may be important in determining sperm architecture and male fertility. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317658
  • ENSP00000326238
  • ENSG00000177938

Symbol
  • CAPAA3
  • GSG3
  • Gsg3
  • CAPPA3
  • HEL-S-86
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
cellular component
0.65
cell line
0.61
virus perturbation
0.5
biological process
0.43


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.38   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.38   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
1
2
22.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
22.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
capping actin protein of muscle Z-line subunit alpha 3
VGNC:12859
465323
Macaque
capping actin protein of muscle Z-line alpha subunit 3
703410
Mouse
MGI:106221
12344
Rat
RGD:2271
29324
Dog
capping actin protein of muscle Z-line subunit alpha 3
VGNC:38712
477680
Species
Name
OMA
EggNOG
Inparanoid
Chimp
capping actin protein of muscle Z-line subunit alpha 3
Macaque
capping actin protein of muscle Z-line alpha subunit 3
Mouse
Rat
Dog
capping actin protein of muscle Z-line subunit alpha 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96KX2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
Cellular responses to external stimuli
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (228)
1 – 10 of 228
CAPZB
Tbio
Novelty: 0.03509224
Score: 0.985
Data Source: Reactome,STRINGDB
CAPZA2
Tbio
Novelty: 0.14014918
Score: 0.938
Data Source: STRINGDB
DCTN2
Tbio
Novelty: 0.01045432
Score: 0.936
Data Source: Reactome,STRINGDB
DYNC1LI2
Tbio
Novelty: 0.17381295
Score: 0.924
Data Source: Reactome,STRINGDB
KIF2B
Tbio
Novelty: 0.09958244
Score: 0.923
Data Source: STRINGDB
DCTN5
Tdark
Novelty: 0.19530162
Score: 0.922
Data Source: Reactome,STRINGDB
DYNC1LI1
Tbio
Novelty: 0.02164556
Score: 0.919
Data Source: Reactome,STRINGDB
ACTR1A
Tbio
Novelty: 0.06306209
Score: 0.918
Data Source: Reactome,STRINGDB
ACTR1B
Tbio
Novelty: 0.10014723
Score: 0.918
Data Source: STRINGDB
ACTR10
Tbio
Novelty: 0.11388846
Score: 0.918
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  3.38

PubMed score by year
PubTator Score  3.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer