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Tbio
PHACTR3
Phosphatase and actin regulator 3

Protein Summary
Description
This gene encodes a member of the phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it functions as a regulatory subunit of protein phosphatase-1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355648
  • ENSP00000347866
  • ENSG00000087495
  • ENST00000359926
  • ENSP00000353002
  • ENST00000361300
  • ENSP00000354555
  • ENST00000371015
  • ENSP00000360054
  • ENST00000395636
  • ENSP00000378998
  • ENST00000541461
  • ENSP00000442483

Symbol
  • C20orf101
  • SCAPIN1
  • H17739
  • SCAPIN1
  • PPP1R123
  • SCAPININ
  • C20orf101
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.77
cell type or tissue
0.72
trait
0.61
molecular function
0.6
PubMedID
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.77   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.77   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
2
2
68.1
intelligence
2
5
4
5.5
57.7
cognitive function measurement
1
1
1
49.5
mathematical ability
1
2
2
45.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
68.1
intelligence
4
5.5
57.7
cognitive function measurement
1
49.5
mathematical ability
2
45.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
phosphatase and actin regulator 3
701648
Mouse
MGI:1921439
74189
Rat
RGD:1303029
362284
Dog
phosphatase and actin regulator 3
VGNC:44474
612028
Horse
phosphatase and actin regulator 3
VGNC:21365
100050984
Species
Name
OMA
EggNOG
Inparanoid
Macaque
phosphatase and actin regulator 3
Mouse
Rat
Dog
phosphatase and actin regulator 3
Horse
phosphatase and actin regulator 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96KR7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (45)
1 – 10 of 45
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
Score:  0.96
Data Source:  STRINGDB
PPP1CB
Tbio
Family:  Enzyme
Novelty:  0.0122614
Score:  0.942
Data Source:  STRINGDB
BCAS4
Tbio
Novelty:  0.11759439
Score:  0.703
Data Source:  STRINGDB
PFDN4
Tbio
Novelty:  0.02133605
Score:  0.691
Data Source:  STRINGDB
RBM38
Tbio
Novelty:  0.03491566
Score:  0.677
Data Source:  STRINGDB
CTCFL
Tbio
Family:  TF
Novelty:  0.00858527
Score:  0.669
Data Source:  STRINGDB
FAM19A4
Tbio
Novelty:  0.04305684
Score:  0.63
Data Source:  STRINGDB
FAM209B
Tdark
Novelty:  8
Score:  0.56
Data Source:  STRINGDB
CBLN4
Tbio
Novelty:  0.11296355
Score:  0.544
Data Source:  STRINGDB
EIF4ENIF1
Tbio
Novelty:  0.03835664
Score:  0.54
Data Source:  STRINGDB
Publication Statistics
PubMed Score  11.77

PubMed score by year
PubTator Score  7.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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