You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ZFR
Zinc finger RNA-binding protein

Protein Summary
Description
Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). This gene encodes an RNA-binding protein characterized by its DZF (domain associated with zinc fingers) domain. The encoded protein may play a role in the nucleocytoplasmic shuttling of another RNA-binding protein, Staufen homolog 2, in neurons. Expression of this gene is regulated through alternative polyadenylation that mediates differential microRNA targeting. Elevated expression of this gene has been observed in human patients with pancreatic cancer and knockdown of this gene may result in reduced viability and invasion of pancreatic cancer cells. [provided by RefSeq, Sep 2016]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
transcription factor binding site profile
0.83
cell type or tissue
0.7
disease perturbation
0.68
histone modification site profile
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.78   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.78   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (69)
1 – 10 of 69
ILF2
Tbio
Novelty: 0.01598188
p_int: 0.999949937
p_ni: 0.000050063
Score: 0.937
Data Source: BioPlex,STRINGDB
ZYX
Tbio
Novelty: 0.00375452
p_int: 0.999688391
p_ni: 0.000311609
Score: 0.179
Data Source: BioPlex,STRINGDB
HNRNPR
Tbio
Novelty: 0.06568708
p_int: 0.999605908
p_ni: 0.000394092
Score: 0.855
Data Source: BioPlex,STRINGDB
RPS16
Tbio
Novelty: 0.00261983
p_int: 0.996087202
p_ni: 0.003912798
Data Source: BioPlex
ELAVL2
Tbio
Novelty: 0.00370708
p_int: 0.987730062
p_ni: 0.012269938
Score: 0.243
Data Source: BioPlex,STRINGDB
FBXW11
Tbio
Novelty: 0.0715377
p_int: 0.986537969
p_ni: 0.013462031
Data Source: BioPlex
MRPS17
Tdark
Novelty: 0.46103276
p_int: 0.969647543
p_ni: 0.030352457
Data Source: BioPlex
LARP4B
Tbio
Novelty: 0.11363794
p_int: 0.961344593
p_ni: 0.038655407
Score: 0.16
Data Source: BioPlex,STRINGDB
FGF8
Tbio
Novelty: 0.00155113
p_int: 0.94739216
p_ni: 0.05260784
Data Source: BioPlex
APOBEC3D
Tbio
Novelty: 0.01102619
p_int: 0.917574823
p_ni: 0.082425177
Score: 0.306
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  55.78

PubMed score by year
PubTator Score  4.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer