Tchem EHMT2 Histone-lysine N-methyltransferase EHMT2

Protein Summary

Description

Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. This gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this protein results in recruitment of additional epigenetic regulators and repression of transcription. This gene was initially thought to be two different genes, NG36 and G9a, adjacent to each other in the HLA locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• Q96KQ7
• B0UZY2
• Q14349
• Q5JP83
• Q5JQ92
• Q5JQA1
• Q5JQG3
• Q6PK06
• Q96MH5
• Q96QD0
• Q9UQL8
• Q9Y331

Gene Name

• EHMT2

Ensembl ID

• ENST00000375530
• ENSP00000364680
• ENSG00000204371
• ENST00000375537
• ENSP00000364687
• ENST00000383372
• ENSP00000372863
• ENSG00000206376
• ENST00000383373
• ENSP00000372864
• ENST00000420336
• ENSP00000396119
• ENSG00000238134
• ENST00000420874
• ENSP00000411035
• ENSG00000236759
• ENST00000421926
• ENSP00000416957
• ENSG00000232045
• ENST00000429506
• ENSP00000406110
• ENSG00000227333
• ENST00000450075
• ENSP00000392305
• ENST00000450229
• ENSP00000400838

Symbol

• BAT8
• C6orf30
• G9A
• KMT1C
• NG36
• G9A
• BAT8
• GAT8
• NG36
• KMT1C
• C6orf30

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
molecular function	0.81
disease perturbation	0.74
drug perturbation	0.71
disease	0.69

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Writer / Protein Methyltransferase / Histone-lysine N-methyltransferase Ehmt2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 495.28   (req: < 5)

Gene RIFs: 157   (req: <= 3)

Antibodies: 333   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 495.28   (req: >= 5)

Gene RIFs: 157   (req: > 3)

Antibodies: 333   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 247

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2