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Tchem
EHMT2
Histone-lysine N-methyltransferase EHMT2

Protein Summary
Description
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375530
  • ENSP00000364680
  • ENSG00000204371
  • ENST00000375537
  • ENSP00000364687
  • ENST00000383372
  • ENSP00000372863
  • ENSG00000206376
  • ENST00000383373
  • ENSP00000372864
  • ENST00000420336
  • ENSP00000396119
  • ENSG00000238134
  • ENST00000420874
  • ENSP00000411035
  • ENSG00000236759
  • ENST00000421926
  • ENSP00000416957
  • ENSG00000232045
  • ENST00000429506
  • ENSP00000406110
  • ENSG00000227333
  • ENST00000450075
  • ENSP00000392305
  • ENST00000450229
  • ENSP00000400838

Symbol
  • BAT8
  • C6orf30
  • G9A
  • KMT1C
  • NG36
  • G9A
  • BAT8
  • GAT8
  • NG36
  • KMT1C
  • C6orf30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
molecular function
0.81
disease perturbation
0.74
drug perturbation
0.71
disease
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 495.28   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 333   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 495.28   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 333   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 247
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2