You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TNIP3
TNFAIP3-interacting protein 3

Protein Summary
Description
Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000057513
  • ENSP00000057513
  • ENSG00000050730
  • ENST00000507879
  • ENSP00000427106
  • ENST00000509841
  • ENSP00000426613

Symbol
  • ABIN3
  • LIND
  • LIND
  • ABIN-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.97
cellular component
0.64
virus perturbation
0.64
tissue
0.55
tissue sample
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.94   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.94   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
44.2
facial morphology measurement
1
1
1
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
44.2
facial morphology measurement
1
6.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNFAIP3 interacting protein 3
VGNC:719
461463
Macaque
TNFAIP3 interacting protein 3
709178
Mouse
MGI:3041165
414084
Dog
TNFAIP3 interacting protein 3
VGNC:47678
100855775
Horse
TNFAIP3 interacting protein 3
VGNC:24383
100072294
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNFAIP3 interacting protein 3
Macaque
TNFAIP3 interacting protein 3
Mouse
Dog
TNFAIP3 interacting protein 3
Horse
TNFAIP3 interacting protein 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96KP6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (97)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Ovarian tumor domain proteases
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Ovarian tumor domain proteases
Post-translational protein modification
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (22)
1 – 10 of 22
TNFAIP3
Tbio
Novelty:  0.00257088
Score:  0.971
Data Source:  Reactome,STRINGDB
TNIP2
Tbio
Novelty:  0.03640252
Score:  0.669
Data Source:  STRINGDB
GPBP1
Tbio
Novelty:  0.18802498
Score:  0.657
Data Source:  STRINGDB
DRG2
Tbio
Novelty:  0.03293987
Score:  0.643
Data Source:  STRINGDB
ZCCHC4
Tdark
Novelty:  0.3370692
Score:  0.637
Data Source:  STRINGDB
MLF1
Tbio
Novelty:  0.0239522
Score:  0.599
Data Source:  STRINGDB
EAPP
Tbio
Novelty:  0.06519266
Score:  0.596
Data Source:  STRINGDB
GSTZ1
Tbio
Family:  Enzyme
Novelty:  0.00929957
Score:  0.594
Data Source:  STRINGDB
CNOT9
Tbio
Novelty:  0.05592835
Score:  0.593
Data Source:  STRINGDB
EMC4
Tbio
Novelty:  0.12174476
Score:  0.592
Data Source:  STRINGDB
Publication Statistics
PubMed Score  36.94

PubMed score by year
PubTator Score  199

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer