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Tbio
CNDP2
Cytosolic non-specific dipeptidase

Protein Summary
Description
Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880). Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343). CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324262
  • ENSP00000325548
  • ENSG00000133313
  • ENST00000324301
  • ENSP00000325756
  • ENST00000579847
  • ENSP00000462311

Symbol
  • CN2
  • CPGL
  • HEL-S-13
  • PEPA
  • CN2
  • CPGL
  • PEPA
  • HsT2298
  • HEL-S-13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.87
virus perturbation
0.83
tissue
0.75
transcription factor
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 660   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 363   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 660   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 363   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
1
1
17.8
testosterone measurement
1
1
1
12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
17.8
testosterone measurement
1
12
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carnosine dipeptidase 2
VGNC:14786
455473
Macaque
carnosine dipeptidase 2
695080
Mouse
MGI:1913304
66054
Rat
RGD:1305827
291394
Dog
carnosine dipeptidase 2
VGNC:39392
476166
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carnosine dipeptidase 2
Macaque
carnosine dipeptidase 2
Mouse
Rat
Dog
carnosine dipeptidase 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96KP4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Glutathione synthesis and recycling
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glutathione conjugation
Glutathione synthesis and recycling
Metabolism
Phase II - Conjugation of compounds
Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (100)
1 – 10 of 100
CNDP1
Tbio
Family:  Enzyme
Novelty:  0.0102642
p_int:  0.994151994
p_ni:  0.005848006
Score:  0.954
Data Source:  BioPlex,STRINGDB
LAGE3
Tdark
Novelty:  0.02099961
p_int:  0.969323502
p_ni:  0.030676498
Data Source:  BioPlex
LRRC36
Tdark
Novelty:  2.03789632
p_int:  0.896822818
p_ni:  0.103177182
Score:  0.332
Data Source:  BioPlex,STRINGDB
C8orf34
Tdark
Novelty:  0.25922336
p_int:  0.847970154
p_ni:  0.152029846
Score:  0.54
Data Source:  BioPlex,STRINGDB
NSUN2
Tbio
Family:  Enzyme
Novelty:  0.01546947
p_int:  0.8314518
p_ni:  0.1685482
Score:  0.239
Data Source:  BioPlex,STRINGDB
CARNS1
Tbio
Family:  Enzyme
Novelty:  0.09322055
Score:  0.954
Data Source:  STRINGDB
CARNMT1
Tbio
Family:  Enzyme
Novelty:  0.28121779
Score:  0.948
Data Source:  STRINGDB
ALDH9A1
Tbio
Family:  Enzyme
Novelty:  0.01688006
Score:  0.933
Data Source:  STRINGDB
HDC
Tbio
Family:  Enzyme
Novelty:  0.00193646
Score:  0.929
Data Source:  STRINGDB
UPB1
Tbio
Family:  Enzyme
Novelty:  0.01797327
Score:  0.917
Data Source:  STRINGDB
Publication Statistics
PubMed Score  660.00

PubMed score by year
PubTator Score  265.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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