Tbio EXOC2 Exocyst complex component 2

Protein Summary

Description

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q96KP1
• B2RBE6
• Q5JPC8
• Q96AN6
• Q9NUZ8
• Q9UJM7

Gene Name

• EXOC2

Ensembl ID

• ENST00000230449
• ENSP00000230449
• ENSG00000112685

Symbol

• SEC5
• SEC5L1
• SEC5
• Sec5p
• SEC5L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
kinase perturbation	0.84
transcription factor binding site profile	0.79
histone modification site profile	0.77
phenotype	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.45   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 122   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.45   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0