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Tbio
EXOC2
Exocyst complex component 2

Protein Summary
Description
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230449
  • ENSP00000230449
  • ENSG00000112685

Symbol
  • SEC5
  • SEC5L1
  • SEC5
  • Sec5p
  • SEC5L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
kinase perturbation
0.84
transcription factor binding site profile
0.79
histone modification site profile
0.77
phenotype
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.06   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.06   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (18)
Cargo trafficking to the periciliary membrane (R-HSA-5620920)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Insulin processing
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Cargo trafficking to the periciliary membrane
Cilium Assembly
Insulin processing
Membrane Trafficking
Metabolism of proteins
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (205)
1 – 10 of 205
EXOC3
Tbio
Novelty: 0.01423005
p_int: 0.999999669
p_ni: 3.31e-7
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOC1
Tbio
Novelty: 0.01279762
p_int: 0.999994695
p_ni: 0.000005305
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOC6
Tbio
Novelty: 0.02897817
p_int: 0.999921363
p_ni: 0.00007863
p_wrong: 7e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
IL1R2
Tbio
Novelty: 0.01061944
p_int: 0.999864646
p_ni: 0.000135354
Score: 0.764
Data Source: BioPlex,STRINGDB
EXOC8
Tbio
Novelty: 0.06047806
p_int: 0.994056745
p_ni: 0.005943252
p_wrong: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
EDNRB
Tclin
Family: GPCR
Novelty: 0.00055047
p_int: 0.963387348
p_ni: 0.036612652
Score: 0.521
Data Source: BioPlex,STRINGDB
APLNR
Tchem
Family: GPCR
Novelty: 0.001441
p_int: 0.949602439
p_ni: 0.050397504
p_wrong: 5.7e-8
Data Source: BioPlex
CHRM3
Tclin
Family: GPCR
Novelty: 0.00207684
p_int: 0.943786631
p_ni: 0.056213332
p_wrong: 3.7e-8
Data Source: BioPlex
BSG
Tbio
Novelty: 0.00077805
p_int: 0.893919608
p_ni: 0.106080391
p_wrong: 1e-9
Data Source: BioPlex
CMKLR1
Tchem
Family: GPCR
Novelty: 0.00748603
p_int: 0.794343193
p_ni: 0.205648566
p_wrong: 0.000008242
Data Source: BioPlex
Publication Statistics
PubMed Score  52.06

PubMed score by year
PubTator Score  51.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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