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Tbio
EXOC2
Exocyst complex component 2

Protein Summary
Description
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230449
  • ENSP00000230449
  • ENSG00000112685

Symbol
  • SEC5
  • SEC5L1
  • SEC5
  • Sec5p
  • SEC5L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
kinase perturbation
0.84
transcription factor binding site profile
0.79
histone modification site profile
0.77
phenotype
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.78   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.78   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
4
6
92.1
suntan
1
2
2
90.9
intraocular pressure measurement
4
2
5
90.4
hair color
2
2
0
1.1
85.7
2
2
0
1.2
82.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
6
92.1
suntan
2
90.9
intraocular pressure measurement
5
90.4
hair color
0
1.1
85.7
0
1.2
82.7
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exocyst complex component 2
VGNC:2782
462387
Macaque
exocyst complex component 2
706296
Mouse
MGI:1913732
66482
Rat
RGD:619961
171455
Dog
exocyst complex component 2
VGNC:40513
478696
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exocyst complex component 2
Macaque
exocyst complex component 2
Mouse
Rat
Dog
exocyst complex component 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96KP1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Cargo trafficking to the periciliary membrane (R-HSA-5620920)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Insulin processing
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Cargo trafficking to the periciliary membrane
Cilium Assembly
Insulin processing
Membrane Trafficking
Metabolism of proteins
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (205)
1 – 10 of 205
EXOC3
Tbio
Novelty: 0.01051955
p_int: 0.999999669
p_ni: 3.31e-7
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOC1
Tbio
Novelty: 0.01073858
p_int: 0.999994695
p_ni: 0.000005305
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOC6
Tbio
Novelty: 0.01886811
p_int: 0.999921363
p_ni: 0.00007863
p_wrong: 7e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
IL1R2
Tbio
Novelty: 0.00820359
p_int: 0.999864646
p_ni: 0.000135354
Score: 0.764
Data Source: BioPlex,STRINGDB
EXOC8
Tbio
Novelty: 0.03090842
p_int: 0.994056745
p_ni: 0.005943252
p_wrong: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
EDNRB
Tclin
Family: GPCR
Novelty: 0.00053875
p_int: 0.963387348
p_ni: 0.036612652
Score: 0.521
Data Source: BioPlex,STRINGDB
APLNR
Tchem
Family: GPCR
Novelty: 0.00224203
p_int: 0.949602439
p_ni: 0.050397504
p_wrong: 5.7e-8
Data Source: BioPlex
CHRM3
Tclin
Family: GPCR
Novelty: 0.00849776
p_int: 0.943786631
p_ni: 0.056213332
p_wrong: 3.7e-8
Data Source: BioPlex
BSG
Tbio
Novelty: 0.0010285
p_int: 0.893919608
p_ni: 0.106080391
p_wrong: 1e-9
Data Source: BioPlex
CMKLR1
Tchem
Family: GPCR
Novelty: 0.00893083
p_int: 0.794343193
p_ni: 0.205648566
p_wrong: 0.000008242
Data Source: BioPlex
Publication Statistics
PubMed Score  62.78

PubMed score by year
PubTator Score  51.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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