Tdark GJD4 Gap junction delta-4 protein

Protein Summary

Description

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Connexins, such as GJD4, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q96KN9
• Q8N2R7

Gene Name

• GJD4

Ensembl ID

• ENST00000321660
• ENSP00000315070
• ENSG00000177291

Symbol

• CX40.1
• CX40.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.72
protein domain	0.58
cell type or tissue	0.51
cell line	0.42
chemical	0.42

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Gap Junction / Gap Junction Delta-4 Protein

DTO Classes

Protein / Cell-cell Junction / Gap Junction / Gap Junction Delta-4 Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.98   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 49   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.98   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0