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Tbio
PKNOX2
Homeobox protein PKNOX2

Protein Summary
Description
Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298282
  • ENSP00000298282
  • ENSG00000165495

Symbol
  • PREP2
  • PREP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.69
microRNA
0.65
transcription factor binding site profile
0.65
PubMedID
0.63
disease
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.86   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.86   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
PBX4
Tbio
Family:  TF
Novelty:  0.09471693
p_int:  0.999999999
p_ni:  1e-9
Score:  0.475
Data Source:  BioPlex,STRINGDB
C5orf24
Tdark
Novelty:  3.95177775
p_int:  0.999999711
p_ni:  9e-8
p_wrong:  1.99e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
LMX1B
Tbio
Family:  TF
Novelty:  0.00405645
p_int:  0.999999274
p_ni:  4.73e-7
p_wrong:  2.52e-7
Score:  0.354
Data Source:  BioPlex,STRINGDB
VWA5A
Tbio
Novelty:  0.0802354
p_int:  0.999817803
p_ni:  2.87e-7
p_wrong:  0.000181911
Score:  0.208
Data Source:  BioPlex,STRINGDB
CCDC120
Tbio
Novelty:  0.48574876
p_int:  0.999779507
p_ni:  2.31e-7
p_wrong:  0.000220261
Data Source:  BioPlex
C16orf71
Tdark
Novelty:  0.97826087
p_int:  0.999777845
p_ni:  0.000004544
p_wrong:  0.000217611
Score:  0.165
Data Source:  BioPlex,STRINGDB
DDX25
Tbio
Family:  Enzyme
Novelty:  0.04593291
Score:  0.904
Data Source:  STRINGDB
HYLS1
Tbio
Novelty:  0.03257577
Score:  0.903
Data Source:  STRINGDB
HOXB1
Tbio
Family:  TF
Novelty:  0.00731831
Score:  0.829
Data Source:  STRINGDB
HOXB2
Tbio
Family:  TF
Novelty:  0.015749
Score:  0.73
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Model (ISM)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
4
86
testosterone measurement
4
1
4
70.5
childhood onset asthma
1
1
0
1.1
57.8
1
1
0
1.1
54.4
1
1
0
1.1
52.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
86
testosterone measurement
4
70.5
childhood onset asthma
0
1.1
57.8
0
1.1
54.4
0
1.1
52.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PBX/knotted 1 homeobox 2
VGNC:14181
451646
Macaque
PBX/knotted 1 homeobox 2
713041
Mouse
MGI:2445415
208076
Rat
RGD:1590611
680549
Dog
PBX/knotted 1 homeobox 2
VGNC:44615
479399
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PBX/knotted 1 homeobox 2
Macaque
PBX/knotted 1 homeobox 2
Mouse
Rat
Dog
PBX/knotted 1 homeobox 2
Publication Statistics
PubMed Score 49.86
PubMed score by year
PubTator Score 15.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title