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Tbio
CNDP1
Beta-Ala-His dipeptidase

Protein Summary
Description
This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358821
  • ENSP00000351682
  • ENSG00000150656

Symbol
  • CN1
  • CPGL2
  • CN1
  • CPGL2
  • HsT2308
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.74
gene perturbation
0.71
protein domain
0.58
disease
0.53
molecular function
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.3   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.3   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (80)
1 – 10 of 80
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.998227282
p_ni:  0.001772716
p_wrong:  1e-9
Data Source:  BioPlex
CNDP2
Tbio
Family:  Enzyme
Novelty:  0.00157228
p_int:  0.994151994
p_ni:  0.005848006
Score:  0.954
Data Source:  BioPlex,STRINGDB
SLC16A10
Tbio
Family:  Transporter
Novelty:  0.02363735
p_int:  0.972659725
p_ni:  0.021824044
p_wrong:  0.00551623
Score:  0.278
Data Source:  BioPlex,STRINGDB
RAB3B
Tbio
Family:  Enzyme
Novelty:  0.02731183
p_int:  0.961197419
p_ni:  0.01501117
p_wrong:  0.023791411
Score:  0.186
Data Source:  BioPlex,STRINGDB
MANEA
Tbio
Family:  Enzyme
Novelty:  0.03693244
p_int:  0.929812105
p_ni:  0.07018788
p_wrong:  1.5e-8
Score:  0.186
Data Source:  BioPlex,STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
p_int:  0.901555575
p_ni:  0.098441636
p_wrong:  0.00000279
Score:  0.194
Data Source:  BioPlex,STRINGDB
SLC25A16
Tbio
Family:  Transporter
Novelty:  0.00778831
p_int:  0.900779885
p_ni:  0.099190843
p_wrong:  0.000029273
Score:  0.167
Data Source:  BioPlex,STRINGDB
HSP90AB4P
Tdark
p_int:  0.848856318
p_ni:  0.151143682
Data Source:  BioPlex
COX7A2
Tbio
Family:  Enzyme
Novelty:  0.04287864
p_int:  0.804102899
p_ni:  0.195626906
p_wrong:  0.000270194
Score:  0.232
Data Source:  BioPlex,STRINGDB
PIGM
Tbio
Family:  Enzyme
Novelty:  0.02186069
p_int:  0.779579445
p_ni:  0.21979261
p_wrong:  0.000627945
Score:  0.212
Data Source:  BioPlex,STRINGDB
Pathways (6)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Histidine metabolism
KEGG
Arginine and proline metabolism
KEGG
beta-Alanine metabolism
KEGG
Metabolic pathways
Name
Explore in Pharos
Explore in Source
Histidine metabolism
Arginine and proline metabolism
beta-Alanine metabolism
Metabolic pathways
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
17.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carnosine dipeptidase 1
VGNC:14787
455474
Macaque
carnosine dipeptidase 1
695195
Mouse
MGI:2451097
338403
Rat
RGD:1359493
307212
Dog
carnosine dipeptidase 1
VGNC:39391
476165
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carnosine dipeptidase 1
Macaque
carnosine dipeptidase 1
Mouse
Rat
Dog
carnosine dipeptidase 1
Publication Statistics
PubMed Score 111.30
PubMed score by year
PubTator Score 79.77
PubTator score by year