You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HIST1H2AH
Histone H2A type 1-H

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377459
  • ENSP00000366679
  • ENSG00000274997

Symbol
  • HIST1H2AI
  • H2AH
  • H2A/S
  • H2AFALii
  • dJ86C11.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.83
transcription factor binding site profile
0.7
cell line
0.65
histone modification site profile
0.51
protein complex
0.46


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.45   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.45   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
6
6
83.5
self reported educational attainment
2
2
2
70.5
3
3
0
1.2
68.8
intelligence
2
3
2
6.9
64.9
1
2
0
1.1
57.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
6
83.5
self reported educational attainment
2
70.5
0
1.2
68.8
intelligence
2
6.9
64.9
0
1.1
57.2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96KK5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Deubiquitination
Reactome
HATs acetylate histones
Reactome
HDACs deacetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Deubiquitination
HATs acetylate histones
HDACs deacetylate histones
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (173)
1 – 10 of 173
HIST1H2AJ
Tdark
Novelty:  0.70360784
Score:  0.996
Data Source:  STRINGDB
HIST2H2AC
Tbio
Novelty:  0.00065524
Score:  0.996
Data Source:  STRINGDB
HIST2H2AB
Tbio
Novelty:  0.06772132
Score:  0.996
Data Source:  STRINGDB
HIST1H2AC
Tdark
Novelty:  0.4785744
Score:  0.994
Data Source:  STRINGDB
H2AFJ
Tbio
Novelty:  0.34726304
Score:  0.994
Data Source:  STRINGDB
HIST1H2BB
Tbio
Novelty:  0.20192804
Score:  0.983
Data Source:  STRINGDB
HIST1H2BN
Tbio
Novelty:  0.02592521
Score:  0.983
Data Source:  STRINGDB
HIST2H2BE
Tbio
Novelty:  0.00024381
Score:  0.982
Data Source:  STRINGDB
HIST1H2BL
Tdark
Novelty:  0.64500134
Score:  0.98
Data Source:  STRINGDB
HIST1H2BJ
Tbio
Novelty:  0.14308844
Score:  0.979
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.45

PubMed score by year
PubTator Score  3.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: