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Tbio
COX4I2
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

Protein Summary
Description
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376075
  • ENSP00000365243
  • ENSG00000131055

Symbol
  • COX4L2
  • COX4
  • COX4B
  • COX4-2
  • COX4L2
  • COXIV-2
  • dJ857M17.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.66
cell type or tissue
0.63
cellular component
0.6
molecular function
0.6
tissue
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.47   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.47   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
93.4
platelet crit
2
1
2
85.7
platelet count
2
1
2
84.2
putamen volume
2
2
0
8.7
81.6
eosinophil percentage of leukocytes
1
1
1
78.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
93.4
platelet crit
2
85.7
platelet count
2
84.2
putamen volume
0
8.7
81.6
eosinophil percentage of leukocytes
1
78.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 4I2
VGNC:9832
469913
Macaque
cytochrome c oxidase subunit IV isoform 2 (lung)
713095
Mouse
MGI:2135755
84682
Rat
RGD:69422
84683
Dog
cytochrome c oxidase subunit 4I2
VGNC:54289
485825
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 4I2
Macaque
cytochrome c oxidase subunit IV isoform 2 (lung)
Mouse
Rat
Dog
cytochrome c oxidase subunit 4I2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96KJ9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (95)
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Non-alcoholic fatty liver disease (NAFLD)
KEGG
Alzheimer disease
KEGG
Huntington disease
KEGG
Thermogenesis
KEGG
Cardiac muscle contraction
Name
Explore in Pharos
Explore in Source
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer disease
Huntington disease
Thermogenesis
Cardiac muscle contraction
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (131)
1 – 10 of 131
COX6A2
Tbio
Family:  Enzyme
Novelty:  0.05368739
Score:  0.985
Data Source:  STRINGDB
COX5A
Tbio
Family:  Enzyme
Novelty:  0.02110193
Score:  0.981
Data Source:  STRINGDB
COX5B
Tbio
Family:  Enzyme
Novelty:  0.01729026
Score:  0.979
Data Source:  STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.967
Data Source:  STRINGDB
UQCRFS1
Tbio
Novelty:  0.00341256
Score:  0.965
Data Source:  STRINGDB
CYC1
Tchem
Novelty:  0.01369865
Score:  0.954
Data Source:  STRINGDB
COX6C
Tbio
Family:  Enzyme
Novelty:  0.04365165
Score:  0.941
Data Source:  STRINGDB
COX6B2
Tbio
Family:  Enzyme
Novelty:  0.1103017
Score:  0.932
Data Source:  STRINGDB
COX6B1
Tbio
Family:  Enzyme
Novelty:  0.02531055
Score:  0.93
Data Source:  STRINGDB
UQCR10
Tbio
Novelty:  0.04536078
Score:  0.925
Data Source:  STRINGDB
Publication Statistics
PubMed Score  90.47

PubMed score by year
PubTator Score  11.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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