Tbio DNAJC1 DnaJ homolog subfamily C member 1

Protein Summary

Description

May modulate protein synthesis. The membrane protein encoded by this gene is a DNAJ-like heat shock protein that binds the molecular chaperone BiP. In addition, the encoded protein contains two SANT domains that have been shown to bind serpin alpha1-antichymotrypsin and inter-alpha trypsin inhibitor heavy chain 4. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q96KC8
• B0YIZ8
• Q5VX89
• Q9H6B8

Gene Name

• DNAJC1

Ensembl ID

• ENST00000376980
• ENSP00000366179
• ENSG00000136770

Symbol

• HTJ1
• HTJ1
• MTJ1
• ERdj1
• DNAJL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
transcription factor perturbation	0.84
transcription factor binding site profile	0.83
disease perturbation	0.79
protein domain	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.8   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.8   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0