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Tchem
PBK
Lymphokine-activated killer T-cell-originated protein kinase

Protein Summary
Description
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301905
  • ENSP00000301905
  • ENSG00000168078
  • ENST00000522944
  • ENSP00000428489

Symbol
  • TOPK
  • SPK
  • CT84
  • TOPK
  • HEL164
  • Nori-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
molecular function
0.91
histone modification site profile
0.88
biological process
0.76
gene perturbation
0.75


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 379.43   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 512   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 379.43   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 512   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PDZ binding kinase
VGNC:825
464496
Macaque
PDZ binding kinase
713242
Mouse
MGI:1289156
52033
Rat
RGD:1309565
290326
Dog
PDZ binding kinase
477371
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PDZ binding kinase
Macaque
PDZ binding kinase
Mouse
Rat
Dog
PDZ binding kinase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96KB5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (238)
Items per page:
1 – 5 of 238
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
WikiPathways
4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
WikiPathways
4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
WikiPathways
4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
WikiPathways
4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
Name
Explore in Pharos
Explore in Source
4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (258)
1 – 10 of 258
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.999999447
p_ni: 2e-9
p_wrong: 5.51e-7
Score: 0.219
Data Source: BioPlex,STRINGDB
ARRDC1
Tbio
Novelty: 0.10481621
p_int: 0.999952104
p_ni: 0.000047895
p_wrong: 1e-9
Score: 0.204
Data Source: BioPlex,STRINGDB
DOK4
Tbio
Novelty: 0.06349482
p_int: 0.99967731
p_ni: 0.000322689
Score: 0.271
Data Source: BioPlex,STRINGDB
TRMT2A
Tbio
Family: Enzyme
Novelty: 0.15277091
p_int: 0.9995626
p_ni: 0.000437397
p_wrong: 4e-9
Score: 0.16
Data Source: BioPlex,STRINGDB
MSL1
Tbio
Novelty: 3.71231442
p_int: 0.999280699
p_ni: 0.0007193
p_wrong: 1e-9
Score: 0.295
Data Source: BioPlex,STRINGDB
FAM19A3
Tdark
Novelty: 0.37183557
p_int: 0.999140471
p_ni: 0.000859527
p_wrong: 1e-9
Data Source: BioPlex
LGALS9B
Tdark
Novelty: 1.81752614
p_int: 0.998476636
p_ni: 0.000101657
p_wrong: 0.001421707
Score: 0.862
Data Source: BioPlex,STRINGDB
SNRNP27
Tbio
Novelty: 0.0175187
p_int: 0.997049035
p_ni: 0.002950965
Data Source: BioPlex
TGIF2LY
Tdark
Family: TF
p_int: 0.995754885
p_ni: 0.004229447
p_wrong: 0.000015667
Data Source: BioPlex
ZNF414
Tdark
Novelty: 1.29024829
p_int: 0.991194651
p_ni: 0.008804458
p_wrong: 8.91e-7
Score: 0.182
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  379.43

PubMed score by year
PubTator Score  124.16

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer