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Tdark
TMEM87B
Transmembrane protein 87B

Protein Summary
Description
May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). This gene encodes a protein that may interact with human papillomavirus type 18 E6 oncogene. The protein is also likely to be involved in endosome-to-trans-Golgi network retrograde transport. The gene is expressed in adult and fetal tissues, including brain and heart. This gene is a component of the 2q13 deletion syndrome. Mutations in this gene may be associated with congenital heart defects. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283206
  • ENSP00000283206
  • ENSG00000153214
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.87
histone modification site profile
0.82
transcription factor binding site profile
0.82
cell type or tissue
0.72
phenotype
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.83   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.83   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
1
1
61
aspartate aminotransferase measurement
2
2
1
6.1
60.8
neutrophil count
1
1
1
58.4
systolic blood pressure
1
1
1
53.7
1
1
0
1.1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
61
aspartate aminotransferase measurement
1
6.1
60.8
neutrophil count
1
58.4
systolic blood pressure
1
53.7
0
1.1
50.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 87B
VGNC:409
739724
Macaque
transmembrane protein 87B
698581
Mouse
MGI:1919727
72477
Rat
RGD:1307907
362212
Dog
transmembrane protein 87B
VGNC:47610
611784
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 87B
Macaque
transmembrane protein 87B
Mouse
Rat
Dog
transmembrane protein 87B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96K49-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
GOC
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (34)
1 – 10 of 34
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.99905286
p_ni:  0.000941179
p_wrong:  0.000005961
Score:  0.186
Data Source:  BioPlex,STRINGDB
HFE
Tbio
Novelty:  0.00042077
p_int:  0.985941285
p_ni:  0.013836569
p_wrong:  0.000222146
Data Source:  BioPlex
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
p_int:  0.967414423
p_ni:  0.03186333
p_wrong:  0.000722247
Data Source:  BioPlex
TMED6
Tdark
Novelty:  0.598611
p_int:  0.752072093
p_ni:  0.186810502
p_wrong:  0.061117405
Score:  0.198
Data Source:  BioPlex,STRINGDB
GPR107
Tbio
Family:  GPCR
Novelty:  0.11706099
Score:  0.645
Data Source:  STRINGDB
RBMXL3
Tdark
Novelty:  1.69561146
Score:  0.628
Data Source:  STRINGDB
FBLN7
Tbio
Novelty:  0.03423924
Score:  0.62
Data Source:  STRINGDB
ZC3H8
Tbio
Novelty:  0.41677629
Score:  0.58
Data Source:  STRINGDB
GPR173
Tbio
Family:  GPCR
Novelty:  0.0941881
Score:  0.579
Data Source:  STRINGDB
STX16
Tbio
Novelty:  0.02462523
Score:  0.53
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.83

PubMed score by year
PubTator Score  2.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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