Tdark TMEM87B Transmembrane protein 87B

Protein Summary

Description

May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). This gene encodes a protein that may interact with human papillomavirus type 18 E6 oncogene. The protein is also likely to be involved in endosome-to-trans-Golgi network retrograde transport. The gene is expressed in adult and fetal tissues, including brain and heart. This gene is a component of the 2q13 deletion syndrome. Mutations in this gene may be associated with congenital heart defects. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• Q96K49
• A8K2M9
• Q1RLN2
• Q53R54

Gene Name

• TMEM87B

Ensembl ID

• ENST00000283206
• ENSP00000283206
• ENSG00000153214

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.87
histone modification site profile	0.82
transcription factor binding site profile	0.82
cell type or tissue	0.72
phenotype	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.66   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.66   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0