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Tbio
FAR2
Fatty acyl-CoA reductase 2

Protein Summary
Description
Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates (PubMed:15220348). It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity). This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000182377
  • ENSP00000182377
  • ENSG00000064763
  • ENST00000536681
  • ENSP00000443291
  • ENST00000547116
  • ENSP00000449349

Symbol
  • MLSTD1
  • MLSTD1
  • SDR10E2
  • HEL-S-81
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.74
cell type or tissue
0.69
cellular component
0.69
tissue sample
0.61
tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.96   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.96   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Metabolism (R-HSA-1430728)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Wax and plasmalogen biosynthesis
Reactome
Wax biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Wax and plasmalogen biosynthesis
Wax biosynthesis
Protein-Protein Interactions (35)
1 – 10 of 35
PEX19
Tbio
Novelty: 0.00469515
p_int: 0.995415565
p_ni: 0.004584435
Score: 0.487
Data Source: BioPlex,STRINGDB
CTLA4
Tclin
Novelty: 0.00017405
p_int: 0.992198304
p_ni: 0.007801696
Data Source: BioPlex
ATP2B2
Tbio
Family: Transporter
Novelty: 0.00724828
p_int: 0.992162036
p_ni: 0.007837964
Score: 0.185
Data Source: BioPlex,STRINGDB
B4GAT1
Tbio
Family: Enzyme
Novelty: 0.06386176
p_int: 0.983664767
p_ni: 0.016335233
Data Source: BioPlex
SLC39A4
Tbio
Family: Transporter
Novelty: 0.00826526
p_int: 0.980178756
p_ni: 0.019821244
Score: 0.157
Data Source: BioPlex,STRINGDB
SCN3B
Tbio
Family: IC
Novelty: 0.08995222
p_int: 0.97123732
p_ni: 0.02876264
p_wrong: 4.1e-8
Data Source: BioPlex
ZP2
Tbio
Novelty: 0.00383063
p_int: 0.960195436
p_ni: 0.039804515
p_wrong: 4.9e-8
Data Source: BioPlex
PCDHGB1
Tdark
Novelty: 2
p_int: 0.93969776
p_ni: 0.06030224
Data Source: BioPlex
SLC39A12
Tbio
Family: Transporter
Novelty: 0.11255353
p_int: 0.919321318
p_ni: 0.08067868
p_wrong: 2e-9
Score: 0.157
Data Source: BioPlex,STRINGDB
TMEM130
Tdark
Novelty: 2.54545455
p_int: 0.914525401
p_ni: 0.085474599
Data Source: BioPlex
Publication Statistics
PubMed Score  15.96

PubMed score by year
PubTator Score  6.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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