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Tbio
PDLIM2
PDZ and LIM domain protein 2

Protein Summary
Description
Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265810
  • ENSP00000265810
  • ENSG00000120913
  • ENST00000308354
  • ENSP00000312634
  • ENST00000339162
  • ENSP00000342035
  • ENST00000397760
  • ENSP00000380867
  • ENST00000397761
  • ENSP00000380868
  • ENST00000409141
  • ENSP00000386868
  • ENST00000409417
  • ENSP00000387084

Symbol
  • SLIM
  • MYSTIQUE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.79
cellular component
0.76
PubMedID
0.75
transcription factor perturbation
0.68
small molecule perturbation
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.91   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.91   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
ACTN4
Tbio
Novelty:  0.0040236
Score:  0.927
Data Source:  STRINGDB
MKRN2
Tbio
Family:  Enzyme
Novelty:  0.14061051
Score:  0.827
Data Source:  STRINGDB
LIMD2
Tbio
Novelty:  0.08706366
Score:  0.718
Data Source:  STRINGDB
MYO6
Tbio
Novelty:  0.01073438
Score:  0.664
Data Source:  STRINGDB
LIN7C
Tbio
Novelty:  0.06778878
Score:  0.663
Data Source:  STRINGDB
ACTN1
Tbio
Novelty:  0.00654004
Score:  0.655
Data Source:  STRINGDB
FLNA
Tbio
Novelty:  0.00156479
Score:  0.621
Data Source:  STRINGDB
MAGI3
Tbio
Family:  Enzyme
Novelty:  0.03968945
Score:  0.611
Data Source:  STRINGDB
MYH9
Tbio
Novelty:  0.0016488
Score:  0.609
Data Source:  STRINGDB
MKRN1
Tbio
Family:  Enzyme
Novelty:  0.04485183
Score:  0.6
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
74.5
platelet count
1
1
1
73.9
platelet crit
1
1
1
73
glomerular filtration rate
2
2
2
70.4
creatinine measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
74.5
platelet count
1
73.9
platelet crit
1
73
glomerular filtration rate
2
70.4
creatinine measurement
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PDZ and LIM domain 2
VGNC:13201
464045
Macaque
PDZ and LIM domain 2 [Source:HGNC Symbol;Acc:HGNC:13992]
Mouse
MGI:2384850
213019
Rat
RGD:1359203
290354
Dog
PDZ and LIM domain 2
VGNC:44384
486123
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PDZ and LIM domain 2
Macaque
PDZ and LIM domain 2 [Source:HGNC Symbol;Acc:HGNC:13992]
Mouse
Rat
Dog
PDZ and LIM domain 2
Publication Statistics
PubMed Score 39.91
PubMed score by year
PubTator Score 24.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title