Tbio MAEL Protein maelstrom homolog

Protein Summary

Description

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity).

Uniprot Accession IDs

• Q96JY0
• B4DY43
• E9JVC3
• Q49AP9
• Q5VZP8
• Q9UIW6

Gene Name

• MAEL

Ensembl ID

• ENST00000367870
• ENSP00000356844
• ENSG00000143194
• ENST00000367872
• ENSP00000356846

Symbol

• CT128
• SPATA35

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
biological process	0.82
cellular component	0.7
cell type or tissue	0.56
PubMedID	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.3   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 58   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.3   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0