Tbio ZFP91 E3 ubiquitin-protein ligase ZFP91

Protein Summary

Description

Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• Q96JP5
• A6NHC4
• A8MSG7
• Q86V47
• Q96JP4
• Q96QA3

Gene Name

• ZFP91

Ensembl ID

• ENST00000316059
• ENSP00000339030
• ENSG00000186660

Symbol

• ZNF757
• PZF
• DMS-8
• DSM-8
• FKSG11
• ZFP-91
• ZNF757

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.94
ligand (protein) perturbation	0.83
transcription factor	0.83
transcription factor perturbation	0.8
microRNA	0.79

Protein Classes

PANTHER Classes

Protein / ... / C2h2 Zinc Finger Transcription Factor / E3 Ubiquitin-protein Ligase Zfp91

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / E3 Ubiquitin-protein Ligase Zfp91

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.24   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 183   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.24   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0