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Tbio
ZFP91
E3 ubiquitin-protein ligase ZFP91

Protein Summary
Description
Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316059
  • ENSP00000339030
  • ENSG00000186660

Symbol
  • ZNF757
  • PZF
  • DMS-8
  • DSM-8
  • FKSG11
  • ZFP-91
  • ZNF757
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.94
ligand (protein) perturbation
0.83
transcription factor
0.83
transcription factor perturbation
0.8
microRNA
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.67   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.67   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
3
1
1
76.5
serum gamma-glutamyl transferase measurement
2
2
2
76.1
heel bone mineral density
1
1
1
66
2
2
0
1.1
64.8
monocyte count
1
1
1
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
76.5
serum gamma-glutamyl transferase measurement
2
76.1
heel bone mineral density
1
66
0
1.1
64.8
monocyte count
1
63.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ZFP91 zinc finger protein
466605
Mouse
MGI:104854
109910
Rat
RGD:628736
246282
Dog
ZFP91 zinc finger protein
475962
Horse
ZFP91 zinc finger protein
100068291
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ZFP91 zinc finger protein
Mouse
Rat
Dog
ZFP91 zinc finger protein
Horse
ZFP91 zinc finger protein
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96JP5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (51)
1 – 10 of 51
ZNF653
Tbio
Family:  TF
Novelty:  1.467544
p_int:  0.999999677
p_ni:  6.8e-8
p_wrong:  2.56e-7
Data Source:  BioPlex
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.999992843
p_ni:  0.000007157
Data Source:  BioPlex
TNFRSF13B
Tbio
Novelty:  0.00338954
p_int:  0.999872412
p_ni:  0.000126492
p_wrong:  0.000001097
Data Source:  BioPlex
CHCHD10
Tbio
Novelty:  0.01659548
p_int:  0.999759755
p_ni:  0.000240148
p_wrong:  9.7e-8
Score:  0.222
Data Source:  BioPlex,STRINGDB
PRM2
Tbio
Novelty:  0.0050028
p_int:  0.999640729
p_ni:  0.00035927
p_wrong:  1e-9
Data Source:  BioPlex
CASQ2
Tbio
Novelty:  0.00775794
p_int:  0.999546644
p_ni:  0.000453236
p_wrong:  1.21e-7
Data Source:  BioPlex
PRDM5
Tbio
Family:  TF; Epigenetic
Novelty:  0.01689997
p_int:  0.996218108
p_ni:  0.00373402
p_wrong:  0.000047872
Data Source:  BioPlex
AURKAIP1
Tchem
Family:  Enzyme
Novelty:  0.19241693
p_int:  0.983752681
p_ni:  0.016186981
p_wrong:  0.000060338
Data Source:  BioPlex
DDX50
Tbio
Family:  Enzyme
Novelty:  0.05314506
p_int:  0.970769122
p_ni:  0.027666302
p_wrong:  0.001564576
Data Source:  BioPlex
DDX54
Tbio
Family:  Enzyme
Novelty:  0.12769464
p_int:  0.967526483
p_ni:  0.031640734
p_wrong:  0.000832782
Data Source:  BioPlex
Publication Statistics
PubMed Score  18.67

PubMed score by year
PubTator Score  12.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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