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Tbio
FEM1C
Protein fem-1 homolog C

Protein Summary
Description
Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274457
  • ENSP00000274457
  • ENSG00000145780

Symbol
  • KIAA1785
  • FEM1A
  • EUROIMAGE686608
  • EUROIMAGE783647
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.76
virus perturbation
0.76
disease perturbation
0.74
microRNA
0.71
tissue sample
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.68   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.68   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (179)
CUL2
Tbio
Novelty:  0.00512916
p_int:  0.999999973
p_ni:  2.2e-8
p_wrong:  5e-9
Score:  0.963
Data Source:  BioPlex,STRINGDB
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.99970602
p_ni:  9e-9
p_wrong:  0.00029397
Data Source:  BioPlex
CUL5
Tbio
Novelty:  0.00792494
p_int:  0.999025821
p_ni:  1.7e-8
p_wrong:  0.000974162
Score:  0.933
Data Source:  BioPlex,STRINGDB
FBXW7
Tbio
Novelty:  0.00180856
Score:  0.95
Data Source:  STRINGDB
DCUN1D2
Tchem
Novelty:  1.02957984
Score:  0.94
Data Source:  STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.939
Data Source:  STRINGDB
BTBD6
Tdark
Novelty:  0.24005804
Score:  0.932
Data Source:  STRINGDB
FBXW2
Tbio
Novelty:  0.01492058
Score:  0.927
Data Source:  STRINGDB
FBXW10
Tbio
Novelty:  0.11629778
Score:  0.927
Data Source:  STRINGDB
FBXW8
Tbio
Novelty:  0.06697145
Score:  0.927
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
50.4
myeloid white cell count
1
1
1
8.2
leukocyte count
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
50.4
myeloid white cell count
1
8.2
leukocyte count
1
5.8
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fem-1 homolog C
VGNC:9064
471604
Mouse
MGI:2444737
240263
Rat
RGD:1309322
302288
Dog
fem-1 homolog C
VGNC:51719
481437
Horse
fem-1 homolog C
VGNC:17989
100064222
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fem-1 homolog C
Mouse
Rat
Dog
fem-1 homolog C
Horse
fem-1 homolog C
Publication Statistics
PubMed Score 11.68
PubMed score by year
PubTator Score 0.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title