Tbio NEURL4 Neuralized-like protein 4

Protein Summary

Description

Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers. The protein encoded by this gene is predicted and it includes two isoforms resulting from two alternatively spliced transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96JN8
• Q6GPI8
• Q96IU9
• Q9H0B0

Gene Name

• NEURL4

Ensembl ID

• ENST00000315614
• ENSP00000319826
• ENSG00000215041
• ENST00000399464
• ENSP00000382390

Symbol

• KIAA1787

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.86
virus perturbation	0.76
disease perturbation	0.74
transcription factor	0.53
transcription factor binding site profile	0.53

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / Neuralized-like Protein 4

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / Neuralized-like Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.6   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 14   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.6   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0