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Tdark
LRRIQ1
Leucine-rich repeat and IQ domain-containing protein 1

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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.4   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 15   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.4   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
synophrys measurement
1
1
1
40.2
optic disc size measurement
1
1
1
20.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
synophrys measurement
1
40.2
optic disc size measurement
1
20.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeats and IQ motif containing 1
VGNC:13209
452440
Macaque
leucine rich repeats and IQ motif containing 1
699453
Mouse
MGI:1922228
74978
Rat
RGD:1564903
299759
Dog
leucine rich repeats and IQ motif containing 1
VGNC:54214
100683753
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeats and IQ motif containing 1
Macaque
leucine rich repeats and IQ motif containing 1
Mouse
Rat
Dog
leucine rich repeats and IQ motif containing 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96JM4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (64)
1 – 10 of 64
FGFR4
Tclin
Family: Kinase
Novelty: 0.00258329
p_int: 0.999976021
p_ni: 0.000017851
p_wrong: 0.000006128
Score: 0.183
Data Source: BioPlex,STRINGDB
BMPR2
Tchem
Family: Kinase
Novelty: 0.00155912
p_int: 0.999924255
p_ni: 0.000064147
p_wrong: 0.000011597
Score: 0.562
Data Source: BioPlex,STRINGDB
ACVR1
Tchem
Family: Kinase
Novelty: 0.00284646
p_int: 0.999884701
p_ni: 0.000040716
p_wrong: 0.000074584
Score: 0.593
Data Source: BioPlex,STRINGDB
UNC5B
Tbio
Novelty: 0.01474065
p_int: 0.999649173
p_ni: 0.000007726
p_wrong: 0.000343102
Score: 0.362
Data Source: BioPlex,STRINGDB
FGFR2
Tclin
Family: Kinase
Novelty: 0.00066613
p_int: 0.99960992
p_ni: 0.00039007
p_wrong: 1e-8
Score: 0.176
Data Source: BioPlex,STRINGDB
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00555742
p_int: 0.999190859
p_ni: 0.000809098
p_wrong: 4.3e-8
Score: 0.197
Data Source: BioPlex,STRINGDB
PTPRS
Tchem
Family: Enzyme
Novelty: 0.00587115
p_int: 0.999157465
p_ni: 0.000842535
Score: 0.274
Data Source: BioPlex,STRINGDB
ACVR2A
Tchem
Family: Kinase
Novelty: 0.0063932
p_int: 0.998259896
p_ni: 0.001740037
p_wrong: 6.6e-8
Score: 0.208
Data Source: BioPlex,STRINGDB
GTF2IRD1
Tbio
Family: TF
Novelty: 0.01858027
p_int: 0.995652245
p_ni: 0.004342718
p_wrong: 0.000005037
Data Source: BioPlex
BMPR1A
Tchem
Family: Kinase
Novelty: 0.00343928
p_int: 0.995135956
p_ni: 0.004843541
p_wrong: 0.000020503
Score: 0.199
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  0.40

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer